Publications by authors named "Vicent L"
Background: Primary percutaneous coronary intervention (PCI) is the established treatment for ST-segment elevation myocardial infarction (STEMI), but often it is not readily available in low-resource settings. We assessed the safety and efficacy of the pharmaco-invasive strategy compared to primary PCI for STEMI in Latin America.
Methods: MEDLINE, Embase, and Latin American and Caribbean Health Sciences Literature (LILACS) were searched for the period from their inception to September 2023, for studies that compared a pharmaco-invasive strategy vs primary PCI in Latin America.
Background: Heart failure (HF) represents a significant public health challenge, particularly in low- and middle-income countries, where demographic shifts and healthcare disparities influence disease patterns. This study aimed to analyze trends in HF admissions across Peru from 2018 to 2023.
Methods: We conducted a secondary data analysis of emergency department morbidity records of patients aged ≥20 years registered in the National Superintendence of Health (SUSALUD) database.
Aims: Differentiation between patients with Takotsubo syndrome and acute coronary syndrome (ACS) remains a challenge. We performed a systematic review to identify and evaluate diagnostic predictive models to distinguish both conditions.
Methods And Results: We performed an electronic search in PubMed, EMBASE, and Scopus until January 2024.
Background: Our study aims to compare in-hospital management and outcomes in patients with cardiogenic shock due to ST-segment elevation myocardial infarction (STEMI) versus non-ST-segment elevation myocardial infarction (NSTEMI). Methods: We conducted a retrospective cohort study using the National Inpatient Sample database between 2016-2019, including patients with STEMI/NSTEMI complicated by cardiogenic shock. An inverse probability treatment weighting analysis was performed to compare in-hospital management and outcomes between patients with STEMI and NSTEMI.
View Article and Find Full Text PDFBackground: Data are limited that examine potential sex-based disparities in the utilization and complications of septal reduction therapy (SRT) in patients with obstructive hypertrophic cardiomyopathy. Our aim was to assess the use and in-hospital outcomes of SRT, according to sex. We performed a retrospective cohort study using the 2017-2019 National Inpatient Sample database.
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- Cardiogenic shock (AMI-CS) is a severe condition following acute myocardial infarction, showing high rates of morbidity and mortality, especially highlighting ongoing gender disparities in treatment.* -
- A study analyzing data from 151,560 AMI-CS patients found that women were significantly less likely to receive mechanical circulatory support (MCS) and had higher in-hospital mortality rates than men, despite no major differences in bleeding or other complications.* -
- Racial disparities were noted, with female patients from all racial backgrounds receiving less MCS than their male counterparts, while Black and Hispanic patients had lower MCS utilization compared to White patients, emphasizing the complexities of gender, race, and healthcare access.*
Article Synopsis
- * Methods: A prospective observational study was conducted with 503 AMI patients, assessing their adherence to medications, diet, exercise, and rehabilitation at 6 and 12 months, while also evaluating various predictors through self-administered questionnaires.
- * Results: 85% of patients failed to adhere to at least one recommendation after one year, with factors like caregiver burden and depressive symptoms being more significant in women. Chronic kidney disease and being female were linked to poor adherence specifically to diet, highlighting the need for tailored
Profiling heart failure with preserved or mildly reduced ejection fraction by cluster analysis.
Eur Heart J Qual Care Clin Outcomes
August 2024
Background: Significant knowledge gaps remain regarding the heterogeneity of heart failure (HF) phenotypes, particularly among patients with preserved or mildly reduced left ventricular ejection fraction (HFp/mrEF). Our aim was to identify HF subtypes within the HFp/mrEF population.
Methods: K-prototypes clustering algorithm was used to identify different HF phenotypes in a cohort of 2 570 patients diagnosed with HFmrEF or HFpEF.
Article Synopsis
- Valvular surgery may lower in-hospital mortality for patients with infective endocarditis, especially those at high risk of frailty, according to a study using data from 2016 to 2019.
- In a cohort of 53,275 adult patients, 18.3% underwent surgery; survival rates for low/intermediate frailty patients were similar between surgical and non-surgical groups.
- The study found a significant reduction in mortality for high frailty risk patients who received surgery, highlighting the importance of frailty assessment in treatment decisions.
Article Synopsis
- A study investigated the effects of pulmonary artery catheterization (PAC) in adults with nonischemic cardiogenic shock (CS), as most previous research focused on patients after heart attacks.
- Data was analyzed from over 303,000 hospitalizations between 2017 and 2019, with about 17.5% of these patients receiving PAC during treatment.
- Results showed that those with PAC had lower in-hospital mortality and reduced complications, while also experiencing increased use of advanced support treatments like intra-aortic balloon pumps and heart transplants.
Purpose Of Review: The purpose of this review is to provide an overview of recent evidence on female-specific risk factors related to reproductive status or pregnancy.
Recent Findings: Pregnancy-related factors, including hypertensive disorders and gestational diabetes, increase the risk of heart failure in women, while breastfeeding and hormone therapy may offer protection. Hypertensive disorders of pregnancy, gestational diabetes, polycystic ovarian syndrome, placental abruption, younger maternal age at first live birth, younger maternal age at last live birth, number of stillbirths, number of pregnancies, onset of menstruation before 12 years of age, shorter reproductive age, ovariectomy, and prolonged absence of ovarian hormones may increase the risk of heart failure in women.
Sex differences in population versus in-hospital use of aortic valve replacement procedures in Spain.
Eur Heart J Qual Care Clin Outcomes
January 2025
Article Synopsis
- - The study aims to investigate whether the differences between men and women in the use of aortic valve replacement (AVR) procedures are changing over time, utilizing data from hospitalizations in Spain from 2016 to 2021.
- - Out of 64,384 hospitalizations for aortic stenosis, men were more likely to receive surgical AVR, while women received more transcatheter AVR procedures, though overall, men had higher rates of both types of AVR.
- - By 2020, transcatheter AVR (TAVR) surpassed surgical AVR (SAVR) in prevalence in Spain, with women adopting TAVR earlier despite receiving fewer procedures overall compared to men.
Background: To assess the diagnostic accuracy of the Mayo Clinic echocardiographic criteria for differentiating between constrictive pericarditis and restrictive cardiomyopathy.
Methods: We searched electronic databases for the date range from their inception to July 1, 2022. The index tests were the Mayo Clinic echocardiographic criteria.
Aims: Women may have different management patterns than men in specialised care. Our aim was to assess potential sex differences in referral, management and outcomes of patients attending outpatient cardiac consultations.
Methods And Results: Retrospective observational analysis of patients ≥18 years referred for the first time from primary care to a tertiary hospital cardiology clinic in 2017-2018, comparing reasons for referral, decisions and post-visit outcomes by sex.
Background: High-degree atrioventricular block (HAVB) is a known complication of ST-segment elevation myocardial infarction (STEMI). We aimed to determine the prevalence and prognostic impact of HAVB in a contemporary cohort of STEMI.
Methods: Data were collected from the DIAMANTE registry that included STEMI patients admitted to our cardiac intensive care unit treated with urgent reperfusion.
Article Synopsis
- A study evaluated the effectiveness of hypertonic saline solution (HSS) combined with furosemide against furosemide alone in treating acute decompensated heart failure (ADHF), using data from ten randomized controlled trials with over 3,000 patients.
- Results showed that the combination treatment led to a significant decrease in hospital stay duration, weight, serum creatinine levels, and type-B natriuretic peptide levels, along with increased urine output and serum sodium levels, though quality of evidence varied.
- While the findings support using HSS with furosemide for better outcomes in ADHF patients, more comprehensive studies are necessary to determine impacts on mortality and
Introduction And Objectives: The impact of left ventricular ejection fraction (LVEF) on health care resource utilization (HCRU) and cost in heart failure (HF) patients is not well known. We aimed to compare outcomes, HCRUs and costs according to LVEF groups.
Methods: Retrospective, observational study of all patients with an emergency department (ED) visit or admission to a tertiary hospital in Spain 2018 with a primary HF diagnosis.
Article Synopsis
- The study aimed to assess how coronary artery disease (CAD) influences mortality and readmission rates in patients with heart failure and reduced ejection fraction (HFrEF).
- Out of 1,831 hospitalized heart failure patients, 583 had HFrEF, with 266 having CAD and 137 having idiopathic dilated cardiomyopathy (DCM) as the primary causes.
- Results showed similar one-year mortality and readmission rates for both groups, but those with idiopathic DCM were significantly more likely to receive a heart transplant compared to those with CAD.
Background: Hepatitis B vaccination is necessary for patients with biologic therapies because of the immunomodulatory effect of these drugs. Due to the elevated use of these therapies in the latest years, the research for new vaccination regimens and the improvement of the current ones is essential. New adjuvants like AS04C might be a potential strategy to improve immune response.
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- * Diagnosis has become more effective thanks to advanced imaging techniques, but the process is still complex.
- * Early antibiotic treatment is crucial and should be tailored based on the specific microorganisms and risk factors, as complications frequently lead to significant health issues; most research has focused on adults, limiting its applicability to children.
Introduction And Objectives: The impact of therapeutic improvements in nonrheumatic aortic valve disease (NRAVD) has been assessed at the patient level but not in the whole population with the disease. Our objective was to assess temporal trends in hospitalization rates, treatment and fatality rates in patients with a main or secondary NRAVD diagnosis.
Methods: Retrospective analysis of administrative claims from patients hospitalized with a main or secondary NRAVD diagnosis between 2003 and 2018 in Spain.
Article Synopsis
- The study aimed to determine whether initiating dual antiplatelet therapy early or delaying it is more effective and safer for patients with non-ST-segment elevation acute coronary syndrome (NSTE-ACS).
- After reviewing nine controlled trials involving over 40,000 patients, the findings indicated that delayed prasugrel initiation significantly reduced major adverse cardiovascular events (MACEs) and was deemed the most effective strategy overall.
- Although early prasugrel showed benefits in reducing various secondary cardiovascular outcomes, it increased the risk of bleeding, while delayed clopidogrel had a lower bleeding risk.
Aims: There is controversy regarding the incidence and outcomes of pulmonary embolism (PE) according to sex. Our aim was to address sex differences in temporal trends in main and secondary hospital PE diagnoses, management and case fatality rates (CFR).
Methods And Results: Retrospective analysis of Spain´s National Healthcare System hospital database, years 2003-2019, for patients ≥18 years with main or secondary PE diagnosis.