Publications by authors named "Vicens Diaz de Brito"
Should We Use Rifampicin in Periprosthetic Joint Infections Caused by Staphylococci When the Implant Has Been Exchanged? A Multicenter Observational Cohort Study.
Tobias Siegfried Kramer Alex Soriano Sarah Tedeschi Antonia F Chen Pierre Tattevin Vicens Diaz de Brito
Open Forum Infect Dis
October 2023
Background: Previous studies demonstrated the efficacy of a rifampicin-based regimen in the treatment of acute staphylococcal periprosthetic joint infections (PJIs) treated with surgical debridement. However, evidence is lacking to support the use of rifampicin in cases where the implant is exchanged during revision.
Methods: We included all consecutive cases of staphylococcal PJIs treated from January 2013 to December 2018 with revision surgery in this international, retrospective, multicenter observational cohort study.
Article Synopsis
- The study aimed to determine if patients with an isolated positive sonication fluid culture (SFC) after revision surgery for prosthetic joints have a higher infection rate compared to those with a negative SFC.
- It analyzed data from 95 patients with positive SFC and 201 controls with negative SFC, finding infection rates of 12.6% and 7.0%, respectively, though the difference wasn't statistically significant.
- The findings suggest infections are more common in positive SFC patients, highlighting the need for larger trials to better understand the impact of antibiotic treatment in these cases.