Chronic unexplained anaemia in isolated autoimmune thyroid disease or associated with autoimmune related disorders.

Objective: The prevalence of chronic unexplained anaemia was analysed in patients with autoimmune thyroid disease (ATD).

Design: The presence of chronic unexplained anaemia, defined as anaemia not related to evident or occult bleeding and/or to erythropoietic disorders, was retrospectively assessed and compared in patients with nonautoimmune thyroid disease (NATD) and in patients with ATD.

Subjects And Measurements: Biochemical and morphological parameters of anaemia were investigated and characterized in 1643 consecutive Caucasian outpatients with thyroid disease.

Thyroxine in goiter, Helicobacter pylori infection, and chronic gastritis.

Background: Malabsorption of thyroxine has been described in patients treated with drugs that modify an acidic environment. We determined whether there is an increased need for thyroxine in patients with euthyroid multinodular goiter and impaired secretion of gastric acid.

Methods: We assessed the dose of thyroxine required to obtain a low level of thyrotropin (0.

Increased serum inhibin B levels in postmenopausal women with altered thyroid function.

Hyper- and hypothyroidism have significant effects on the female reproductive system. However, little in the way of data is available on the relationship between ovarian paracrine control and thyroid function. This study was aimed at characterising the serum levels of inhibin B in relation to altered thyroid function.

Reversible increase of serum activin A levels in women with Graves' disease.

The aim of this study was to analyze the serum levels of activin A in hyperthyroid patients with Graves' disease. Serum activin A and FSH levels were measured in a total of 93 females (64 regularly cycling and 29 post-menopausal). Of these, 20 were hyperthyroid patients with Graves disease, 33 were euthyroid goitrous patients (20 had autoimmune thyroiditis AT and 13 only had goiter) representing the internal control group and 40 were healthy subjects representing the external control group.

Age-related prevalence of platelet-associated immunoglobulins G in nonthrombocytopenic patients with autoimmune thyroid disease and autoimmune polyglandular syndrome.

Objective: The prevalence of platelet-associated IgG (paIgG) in nonthrombocytopenic patients with autoimmune thyroid disease (AITD) alone or associated with autoimmune polyglandular syndrome (APS) has been studied.

Subjects: A total of 164 individuals were enrolled in this study: 81 patients with AITD alone, 33 patients with APS, and 50 healthy controls.

Results: The presence of paIgG was recorded in 41 of 81 patients with AITD (51%) as compared with 2 of 50 control subjects (4%, p < 0.

Effect of tryptophan on the early tri-iodothyronine uptake in mouse thymocytes.

Objective: We have studied the effect of tryptophan on cellular [(125)I]tri-iodothyronine (T3) uptake by mouse thymocytes.

Materials And Methods: Mouse thymocytes (20 x 10(6 )cells/ml) were suspended in Krebs-Ringer solution buffered by Tris-HCl and incubation (23 degrees C at pH7.45+/-0.

[The clinical and echographic assessment of thyroid function and structure in patients with a chronic inflammatory intestinal disease].

In Crohn's disease (CD) and in ulcerative colitis (UC) data about possible thyroid involvement are lacking. We studied thyroid morphology and function in 41 patients affected by active inflammatory bowel disease (IBD) (14 UC; 27 CD) before (all) and 45 and 90 days after onset of therapy (23/41), and in 60 normal control subjects. At each time, the following tests were performed: thyroid sonography, hormonal and immunological assays.

Diagnostic items and treatment of Plummer's disease: a study on 180 patients.

Objective: The aim of this study was to evaluate clinical data of patients who have been undergone to medical, radionuclide, surgical and percutaneous ethanol injection (PEI) treatment of autonomous "hot nodule", to establish the real value of these therapeutical strategies.

Patients And Methods: The authors analyzed their experience based on 180 Plummer's disease (PD) from January 1990 to December 1997. 49 nodules have been submitted to FNA.

[Graves' disease: ultrasonographic, color Doppler and histological aspects].

The aim of the present work was to study the relationship between thyroid low echogenicity, the thyroid blood flow by color-Doppler (CD) and histological features in patients with Graves' disease (GD). Thyroid ultrasonography and CD was performed on 28 patients with GD. In 5 patients has been compared CD with histology.

[Variations in the anatomy and physiology of the thyroid gland in old age].

Recently, the anatomical and physiological modifications of thyroid gland in the elderly have been undergone to many investigations. However, it does not exist an univocal interpretation about the results. Furthermore, non-thyroidal diseases, in the elderly, can modify TSH, FT3 and FT4 serum levels because of an important inhibition of T3 and T4 peripheric conversion; moreover, many drugs have been reported interactions with hypothalamus-hypophysis-thyroid axis in the senescence.

Reversible increase of intraocular pressure in subclinical hypothyroid patients.

Objective: The aim of the study was to analyse the relationship between the ocular parameters, namely intraocular pressure (IOP), and the early forms of subclinical hypothyroidism.

Design: Fifty-three subjects (9 male and 44 female) aged from 18 to 45 years (mean 32 +/- 7 years) were selected for this study. Twenty-nine met the criteria of subclinical hypothyroidism and 24 euthyroid subjects, age- and sex-matched, were used as controls.

[Echotomography and color-Doppler in the diagnosis of thyroid carcinoma].

Ultrasound examination of the thyroid gland is used extensively in the diagnosis of thyroid carcinoma: it is easy and rapid to perform and widely available. Ultrasound enables easy identification of the image of disease foci within the gland, especially when high frequency probes (7.5-10 MHz) are used.