In vitro and In silico investigation deciphering novel antifungal activity of endophyte Bacillus velezensis CBMB205 against Fusarium oxysporum.

Endophytes from medicinal plants are potential biocontrol agents against Fusarium oxysporum f. sp. cubense (Foc), which is the causative fungus of banana wilt disease.

Design of Novel Imidazopyrazine Derivative against Breast Cancer Targeted NPY1R Antagonist.

Introduction: Breast cancer is the most frequent malignancy in women with more than one in ten new cancer diagnoses each year. Synthetic products are a key source for the identification of new anticancer medicines and drug leads.

Objectives: Imidazopyrazine is a highly favored skeleton for the design of new anticancer drugs.

Air pollutants: the key stages in the pathway towards the development of cardiovascular disorders.

Air pollution has been one of the significant risks to human health. Various studies indicate that ambient particulate matter in air pollution is most strongly allied to increased morbidity and mortality due to their link with cardiovascular adverse events. The mechanisms leading to these harmful effects on the cardiovascular system have not been defined clearly but several hypotheses have been proposed that elucidate the direct and indirect effects of air pollution.

Micro RNAs: tiny sequences with enormous potential.

MicroRNAs (miRNA) have emerged as critical player in the field of life sciences. These are endogenously expressed small non coding RNAs that function to control post-transcriptional gene expression. These small RNAs have been shown to regulate the cell growth, differentiation and apoptosis.

RNA interference: emerging diagnostics and therapeutics tool.

RNA interference has been recognized to be an efficient mechanism for the sequence specific inhibition of gene-expression caused by 21-23bp long dsRNA. This is a potent tool to study gene function and is ready to lend a hand in the treatment of disease. Two main classes of dsRNA involved are short-interfering RNA and micro RNA which differ in biogenesis and modes of target regulation.