Publications by authors named "Viara Shoumnalieva-Ivanova"
Objective: To evaluate the diagnostic value of peripheral blood microribonucleic acid (miRNA, miR)-146a and miR-155 expression in systemic lupus erythematosus (SLE). Methods: Expression levels of miR-155 and miR-146a in whole peripheral blood samples from 40 SLE patients and 32 healthy controls (HCs) were determined by quantitative reverse transcription-polymerase chain reaction qRT-PCR (SYBR Green technology) and 2-∆∆Ct method was used for analysis. SPSS v20 was used for receiver operating characteristic (ROC) curve and Spearman correlation analysis.
View Article and Find Full Text PDFRationale: Systemic lupus erythematosus (SLE) is a complex autoimmune disease characterized by autoantibody production, complement activation, and deposition of immune complexes in tissues and organs. SLE can involve any region of the visual system. Although ocular manifestations are not part of the classification criteria for SLE, they can be observed in up to one-third of the patients with SLE.
View Article and Find Full Text PDFArticle Synopsis
- - Aagenaes syndrome, or lymphoedema cholestasis syndrome 1 (LSC1), is an inherited condition marked by liver issues (neonatal cholestasis) and chronic swelling (lymphoedema) mainly in the legs, which can get better with age.
- - The syndrome is inherited in an autosomal recessive manner, linked to a specific gene on chromosome 15q, particularly in a 6.6 cM region known as LCS1.
- - Angioid streaks, which are irregular cracks in the eye's membrane, can occur with Aagenaes syndrome and are generally asymptomatic unless they lead to more severe issues. They can also appear in various systemic