Publications by authors named "Vianney Guardiolle"
Background And Objective: Non-invasive ventilation (NIV) improves survival of patients with chronic respiratory failure (CRF). Most often, pressure settings are made to normalize arterial blood gases. However, this objective is not always achieved due to intolerance to increased pressure or poor compliance.
View Article and Find Full Text PDFSusceptibility to mycobacterial infection in VEXAS syndrome.
Rheumatology (Oxford)
February 2024
Article Synopsis
- VEXAS is a newly identified syndrome linked to mutations in the UBA1 gene, which may lead to an increased risk of disseminated non-tuberculous mycobacterial infections (NTMi), despite not being officially recognized as a cause of acquired immunodeficiency.
- In a study of 10 VEXAS patients, two were found with Mycobacterium avium, alongside a review of 20 cases of disseminated NTMi over 13 years, highlighting common conditions among the patients.
- The findings suggest that VEXAS patients may have a higher susceptibility to NTMi due to issues with their immune response, specifically monocytic dysfunction, and emphasize the need for vigilant diagnosis of opportunistic infections before adjusting
Purpose: To describe the management and outcome of critically-ill patients with Cyclophosphamide (CY)-associated cardiac toxicity.
Methods: All patients admitted to the intensive care units (ICUs) of the Nantes and Rennes University Hospitals for a CY-associated cardiac toxicity between January 2015 and December 2020 were included.
Results: Of the thirty-four patients included in the study, twenty-four (70%) underwent allogeneic hematopoietic stem cell transplantation (HSCT), four (12%) autologous HSCT, and six (18%) chemotherapy for hematological malignancies.
Article Synopsis
- Vital status after hospital discharge is crucial for biomedical data warehouses but often lacks reliable data; the French National Mortality Database (FNMD) provides a potential solution, although matching BDW records with FNMD presents various challenges like name changes and clerical errors.
- The study developed a deterministic algorithm using advanced data cleaning techniques and the Damerau-Levenshtein distance to improve the matching process and assessed its performance across records from three university hospitals in France.
- Results showed that the new algorithm had a significantly higher sensitivity (93.3%) compared to a simpler direct matching method (82.7%), especially for men and patients born in France, demonstrating its effectiveness in identifying deceased patients.
Background: To assess the presence of a seasonal effect on fatigue, pain and dryness in primary Sjögren's syndrome (pSS).
Methods: Data (date; visual analogue scales (VAS) for pain, fatigue and dryness) were extracted from three randomised placebo-controlled trials (RCTs) evaluating infliximab (TRIPSS; n = 103 patients), hydroxychloroquine (JOQUER; n = 120 patients) and rituximab (TEARS; n = 120 patients) and from the 5-year follow-up of the ASSESS prospective cohort (n = 395 patients). Data were analysed at each visit for each patient, according to the day, the month of the year and the season.