J Exp Zool A Ecol Integr Physiol
January 2025
AbstractInsulin-like growth factor 1 (IGF-1) is positively linked with growth and reproduction but negatively linked with survival, so a potential role of IGF-1 in modulating life history trade-offs has been proposed. However, the underlying mechanisms of the negative link between IGF-1 and survival are not yet clear, and oxidative stress has been proposed as a candidate. Immune activation is one important source of oxidative stress, and both immune activation and oxidative stress are known to reduce survival.
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