Publications by authors named "Vianala Sunitha"
Article Synopsis
- A new series of -butyl 2-(substituted benzamido) phenylcarbamates was synthesized using -butyl 2-amino phenylcarbamate and various substituted carboxylic acids, resulting in high yields.
- The synthesized compounds were tested for anti-inflammatory activity in rats, showing effectiveness comparable to the standard drug indomethacin, with inhibition rates between 39.021% and 54.239%.
- In silico docking studies were conducted to support the experimental findings and provide further insights into the compounds' potential as anti-inflammatory agents.
Background: Nonsteroidal anti-inflammatory drugs are of vast therapeutic benefit in the treatment of different types of inflammatory conditions. 1,2,3-Triazoles and their derivatives have a wide range of applications as anti-bacterial, anti-fungal, anti-tubercular, cytostatic, anti-HIV, anti-allergic, anti-neoplastic and anti-inflammatory (AI) agents. Considering the individual biological and medicinal importance of ibuprofen and 1,2,3-triazoles, we wanted to explore novel chemical entities based on ibuprofen and triazole moieties towards their biological significance.
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