Publications by authors named "Viacheslav V Kudriavskii"
Biochemistry (Mosc)
August 2024
Article Synopsis
- Expansion of CAG repeats in certain genes is linked to neurodegenerative diseases, but the mechanisms are not well understood; this study investigates how these repeats interact with RNA editing enzymes like ADAR.
- Researchers used induced pluripotent stem cells (iPSCs) and brain organoids from Huntington's disease and ataxia type 17 patients to analyze RNA editing via next-generation sequencing.
- Results showed that while some brain organoids with specific CAG repeats had decreased RNA editing, most cultures did not support the hypothesis that CAG repeats affect editing levels significantly.
