Novel organometallic chloroquine derivative inhibits tumor growth.

Autophagy has emerged as a mechanism critical to both tumorigenesis and development of resistance to multiple lines of anti-cancer therapy. Therefore, targeting autophagy and alternative cell death pathways has arisen as a viable strategy for refractory tumors. The anti-malarial 4-aminoquinoline compounds chloroquine and hydroxychloroquine are currently being considered for re-purposing as anti-cancer therapies intended to sensitize different tumors by targeting the lysosomal cell death pathway.

Electrochemical synthesis of phthalides via anodic activation of aromatic carboxylic acids.

A novel electrochemical synthesis of phthalides was successfully developed using anodically generated aroyloxy radicals in combination with aliphatic carboxylic acid as cheap and readily available alkylating agent precursors.