Publications by authors named "Vetrugno L"

: A tracheostomy is a frequently performed surgical intervention in intensive care units (ICUs) for patients requiring prolonged mechanical ventilation. This procedure can offer significant benefits, including reduced sedation requirements, improved patient comfort, and enhanced airway management. However, it is also associated with various risks, and the absence of standardized clinical guidelines complicates its implementation.

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Objectives: Following cardiac surgery, patients often require ventilatory support during transport to the intensive care unit (ICU). Manual ventilation using a bag valve mask (BVM) is commonly employed; however, mechanical ventilation may sometimes be preferred due to concerns regarding oxygenation, ventilation, and hemodynamic stability. The decision between manual and mechanical ventilation is typically based on clinical experience and surgical factors, as there is no established consensus or robust clinical evidence to guide this choice.

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Article Synopsis
  • The guidelines from the European Society of Anaesthesiology and Intensive Care Medicine (ESAIC) focus on improving patient assessments before surgery to evaluate risks and enhance the surgical experience.
  • A rigorous literature review was conducted, with 17,668 titles initially found, which were narrowed down to 204 relevant studies for a comprehensive analysis using the GRADE methodology.
  • Feedback from ESAIC members was gathered on a draft version of the guidelines, which was then refined and officially approved by the Guidelines Committee and ESAIC Board.
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  • Researchers believe that lung ultrasound scores (LUS) can better predict cardiac risks in elderly patients undergoing hip fracture surgery, compared to existing methods like the Revised Cardiac Risk Index and ASA Physical Status.
  • The study involved 877 patients across 11 Italian hospitals, finding a significant correlation between higher LUS scores and complications, with a notable incidence of major adverse cardiovascular events (MACE).
  • Results showed that a preoperative LUS score of 8 or higher was more effective at predicting MACE than traditional scoring methods, indicating its potential as a valuable tool for risk assessment in this patient population.
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Introduction: Atelectasis is a well-documented complication in pediatric patients undergoing general anesthesia. Its incidence varies significantly based on surgical procedures and anesthesia techniques. Inhalation induction, commonly used to avoid the discomfort of venipuncture, is suspected to cause higher rates of respiratory complications, including atelectasis, compared to intravenous induction.

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  • Postoperative pulmonary complications (PPCs) are a significant issue after esophagectomy, affecting up to 40% of patients despite advances in surgical care.
  • This study aims to determine if using high-flow nasal cannula (HFNC) right after extubation can lower PPC rates compared to standard oxygen therapy.
  • The research involves 320 participants who will be randomly assigned to either HFNC or standard therapy post-surgery, with various complications being tracked to assess the effectiveness of each approach.
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Background: Asthma is a common chronic respiratory disease affecting 1-29% of the population in different countries. Exacerbations represent a change in symptoms and lung function from the patient's usual condition that requires emergency department (ED) admission. Recently, the use of a High-Flow Nasal Cannula (HFNC) plus an in-line vibrating mesh nebulizer (VMN) for aerosol drug delivery has been advocated in clinical practice.

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  • Lung ultrasonography (LUS) is a useful, non-invasive tool for diagnosing respiratory conditions, particularly in resource-limited settings, as it reduces radiation exposure and quantifies regional loss of aeration.
  • A study assessed the agreement among 20 experienced LUS operators by having them evaluate 25 video clips, revealing strong but not perfect inter-rater reliability, with varying levels of consensus on the scores assigned to the clips.
  • Despite some discrepancies, the findings indicate that LUS scoring can reliably inform severity assessments in respiratory diseases, making it a valuable clinical tool.
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Background: Noninvasive ventilation (NIV) is widely employed as the initial treatment for patients with chronic acute exacerbation of obstructive pulmonary disease (AECOPD). Nevertheless, high-flow nasal cannula (HFNC) has been increasingly utilized and investigated to mitigate the issues associated with NIV. Flow rate may play a significant role in diaphragmatic function among subjects recovering from AECOPD.

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Background: Perineal lacerations are a very common complication of post-partum. Usually, the repair of 1st and 2nd-grade lacerations is performed after the administration of local anesthesia. Despite the great relevance of the problem, there are only a few studies about the best choice of local anesthetic to use during suturing.

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Thoracentesis is one of the most important invasive procedures in the clinical setting. Particularly, thoracentesis can be relevant in the evaluation of a new diagnosed pleural effusion, thus allowing for the collection of pleural fluid so that laboratory tests essential to establish a diagnosis can be performed. Furthermore, thoracentesis is a maneuver that can have therapeutic and palliative purposes.

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  • COVID-19, caused by the SARS-CoV-2 virus, has led to millions of deaths and significant lifestyle changes, particularly impacting patients with sepsis in ICUs, where septic complications have a high mortality rate.
  • A clinical study was conducted at SS Annunziata Hospital in Italy, analyzing ICU patients diagnosed with sepsis from 2018 to 2021, dividing them into groups based on the pandemic and COVID-19 status.
  • Out of 1,559 ICU admissions, 211 patients met the sepsis criteria, revealing high mortality rates, especially amongst COVID-19 patients, with a notable relationship between mortality and scores on APACHE III and SOFA assessments.
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Purpose: Growing evidence shows the complex interaction between lung and kidney in critically ill patients. The renal resistive index (RRI) is a bedside measurement of the resistance of the renal blood flow and it is correlated with kidney injury. The positive end-expiratory pressure (PEEP) level could affect the resistance of renal blood flow, so we assumed that RRI could help to monitoring the changes in renal hemodynamics at different PEEP levels.

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Advanced respiratory monitoring encompasses a diverse range of mini- or noninvasive tools used to evaluate various aspects of respiratory function in patients experiencing acute respiratory failure, including those requiring extracorporeal membrane oxygenation (ECMO) support. Among these techniques, key modalities include esophageal pressure measurement (including derived pressures), lung and respiratory muscle ultrasounds, electrical impedance tomography, the monitoring of diaphragm electrical activity, and assessment of flow index. These tools play a critical role in assessing essential parameters such as lung recruitment and overdistention, lung aeration and morphology, ventilation/perfusion distribution, inspiratory effort, respiratory drive, respiratory muscle contraction, and patient-ventilator synchrony.

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Objectives: To investigate the following: (a) effects of intercostal muscle contraction on sonographic assessment of lung sliding and (b) inter-rater and intra-observer agreement on sonographic detection of lung sliding and lung pulse.

Methods: We used Valsalva and Muller maneuvers as experimental models in which closed glottis and clipped nose prevent air from entering the lungs, despite sustained intercostal muscles contraction. Twenty-one healthy volunteers underwent bilateral lung ultrasound during tidal breathing, apnea, hyperventilation, and Muller and Valsalva maneuvers.

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The application of preoperative noninvasive respiratory support (NRS) has been expanding with increasing recognition of its potential role in this setting as a physiological optimization for patients with a high risk of developing atelectasis and postoperative pulmonary complications (PPC). The increased availability of high-performance anesthesia ventilator machines providing an easy way for NRS support in patients with reduced lung function should not be under-evaluated. This support can reduce hypoxia, restore lung volumes and theoretically reduce atelectasis formation after general anesthesia.

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Purpose Of Review: This review explores lung recruitment monitoring, covering techniques, challenges, and future perspectives.

Recent Findings: Various methodologies, including respiratory system mechanics evaluation, arterial bold gases (ABGs) analysis, lung imaging, and esophageal pressure (Pes) measurement are employed to assess lung recruitment. In support to ABGs analysis, the assessment of respiratory mechanics with hysteresis and recruitment-to-inflation ratio has the potential to evaluate lung recruitment and enhance mechanical ventilation setting.

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The application of transthoracic contrast-enhanced ultrasound (CEUS) to the study of peripheral lung lesions is still a topic of debate. The main objective of this review was to evaluate the diagnostic accuracy of CEUS in the diagnosis of malignant subpleural pulmonary consolidations and, therefore, differentiate them from benign ones. Papers published before December 2023 were detected through a search of PubMed, Cochrane library, and Embase.

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Our study investigates the post-mortem findings of the diaphragm's muscular structural changes in mechanically ventilated COVID-19 patients. Diaphragm samples of the right side from 42 COVID-19 critically ill patients were analyzed and correlated with the type and length of mechanical ventilation (MV), ventilatory parameters, prone positioning, and use of sedative drugs. The mean number of fibers was 550±626.

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Article Synopsis
  • Postoperative pulmonary complications remain a significant risk after esophagectomy, and this study explores the benefits of high flow nasal cannula (HFNC) compared to traditional oxygen therapy.
  • The study analyzed 71 cancer patients who underwent esophagectomy between May 2020 and November 2022, comparing those treated with HFNC to a historical cohort using conventional masks.
  • Results revealed that HFNC patients had significantly better ROX index scores and blood gas measurements, though both groups had similar rates of atelectasis and pneumonia; HFNC also showed a trend towards reduced acute respiratory failure.
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Background: Lung ultrasound has demonstrated its usefulness in several respiratory diseases management. One derived score, the Lung Ultrasound (LUS) score, is considered a good outcome predictor in patients with Acute Respiratory Failure (ARF). Nevertheless, it has not been tested in patients undergoing non-invasive respiratory support (NIRS).

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