Biosimilar erythropoietin in anemia treatment (BEAT)-Efficacy and safety of a 1:1 dose conversion from EPREX® to EPIAO® in patients with end-stage renal disease on hemodialysis: A prospective, randomized, double blind, parallel group study.

Background: EPREX®/ERYPO®/PROCRIT® (epoetin alfa, Janssen-Cilag GmbH) was the first available recombinant human erythropoietin (rHuEPO) and was universally reference product as per the recommendation provided by European Medicines Agency. EPIAO® is a biosimilar formulation of EPREX®, and making it a 1:1 dose conversion from EPREX® according to recommendation of European Medicines Agency. This study evaluated the clinical efficacy and safety of EPIAO® in subjects with end-stage renal disease receiving hemodialysis after intravenous administration.

[Adenoma of the parathyroid gland in a young woman with chronic kidney disease: primary or tertiary hyperparathyroidism?].

Clinical observation of a young woman with chronic kidney disease IV stage and hyperparathyroidism is presented. Ultrasound and99mTc-sestamibi scintigraphy of the anterior surface of the neck visualized a tumor of the left upper parathyroid gland. In a histological examination of distant education was diagnosed a solid parathyroid adenoma.

[Impressionable cytology method in diagnostics of dry eye syndrome.].

Analysis of the cellular composition of the eyeball conjunctival prints and evaluation of the informative of the cytomorphological method of research in the diagnosis of dry eye syndrome (DES). Cytological examination using impression cytology was performed in 72 patients: 60 patients with DES and 12 without eye disease (control group). The main component of cytological sample in patients with DES are (a) squamous epithelium (hyperkeratocytes); (b) groups and clusters of flattened epithelial cells; (c) a small amount (up to five in the preparation) of goblet cells.

[Therapeutic pathomorphosis in the practice of clinical cytologists.].

Pathomorphosis means the changes that occur under the influence of various factors during the course of the disease. Therapeutic pathomorphosis develops during diagnostic and therapeutic procedures. The article considers the types of cellular reactions observed in the process of therapeutic pathomorphosis.

[The cytomorphologic characteristics of parathyroid gland under various forms of hyperparathyroidism].

The study was organized to establish criteria of cytological diagnostic of pathology of parathyroid glands under various forms of hyperparathyroidism. The ultrasound examination of pathology of parathyroid glands was applied to 74 patients with hyperparathyroidism aged 24-66 years (20 males and 54 females). The examination was applied to 11 patients with primary hyperparathyroidism (bone visceral form), 51 patients with secondary hyperparathyroidism of severe course and 12 patients with tertiary hyperparathyroidism (post-transplantation).

[The cytomorphologic characteristics of parathyroids under hyperparathyroidism].

The article presents the results of intravital studying of cytomorphologic characteristics of elements of tissue of parathyroids obtained under thin-needle aspiration biopsy in patients with hyperparathyroidism. The analysis was applied to 84 fragments of cell material from node formations in projection of anatomic localization of parathyroids and in projection of lobes and isthmus of thyroid gland. The cytologic preparations colored with Pappenheim azure-eosin staining were analyzed using light microscopy.

[Characteristics of a 24-hour rhythm of blood pressure in patients with chronic renal failure on peritoneal dialysis].

Aim: To analyse 24-h rhythm of blood pressure (BP) and its influence on the rate and severity of left ventricular hypertrophy (LVH) in patients with chronic renal failure (CRF) on replacement therapy (peritoneal dialysis - PD). MATERIAL AND METHODS; 70 CRF patients on PD were studied. Their examination included clinical, biochemical tests, automatic 24-hour blood pressure monitoring, transthoracic echocardiography.

[Composition of amino acid in blood and dialysate by patients with in chronic renal insufficiency by peritoneal dialysis].

Examination composition of amino acid in blood and dialysate by patients with in chronic renal insufficiency by peritoneal dialysis. As it turned out by these patients composition of amino acid in blood and dialysate near. Only variation composition and lowering concentration amino acid with branching chain.

[The application of artificial protein premixes for nutritive support of patients with chronic renal insufficiency, being treated by perinateal dialysis].

As a result of a survey of 56 patients with chronic renal insufficiency, who undergone hemodialysis, it was established, that clinical condition of patients, biochemical and hematological blood indices as well as results of anthropometric research improve upon application of artificial balanced high-protein premixes -"Nutrinil" and "Nutrien-Nefro". Irrespective of way of administration - introperitoneal ("Nutrinil" solution) or enteral ("Nutrien-Nefro" mixture) protein-energetic insufficiency diminishes or totally disappears, body weight, fat and muscle content of the body weight, as well as indices of whole protein, albumine, lymphocytes, haemoglobin, pH approache the norm. Intraperitoneal way of administration of artificial protein premixes increase patients adherence to this procedure, though enteral way of their administration is more preferable from economic point of view.

[The hemodynamic status during ultraviolet irradiation of the blood in patients with chronic nonspecific lung diseases].

Central and organic hemodynamics were studied in extracorporeal UV irradiation of blood (EUVRB) conducted in patients with chronic nonspecific diseases of the lungs. Within the first postexposure day the majority of the hemodynamic parameters showed marked fluctuations. EUVRB brought about a persistent reduction in pulmonary-vascular resistance in bronchial asthma and chronic obstructive bronchitis patients.

[Infectious-inflammatory complications in patients after transplantation of the kidney].

The work deals with the results of retrospective analysis of infectious complications (IC) in 323 patients with terminal renal failure (TRF) who underwent 371 operations for allotransplantation of cadaver kidney (ATCK). IC frequency was 41%, their mortality, 42.6%.

[Ultraviolet irradiation of the blood in the treatment of pyo-inflammatory complications in patients with terminal renal failure].

The authors describe a technique of extracorporeal UV radiation of blood (EUVRB) in flow closed circulation. Its efficacy was assessed in combined treatment of pyo-inflammatory complications of terminal renal failure. Therapeutic effects of EUVRB are due to reduced endogenic intoxication, correction of leukopoiesis and stimulation of immunity.

[Immunologic criteria of severity of suppurative infections in patients on programmed hemodialysis].

Certain parameters of the immune system were studied in patients under programmed hemodialysis with and without pyo-inflammatory complications. It was found that patients without pyo-inflammatory diseases are characterized by the state of immune deficiency while in patients with purulent infection the degree of inhibition of immune response of the organism correlates with spread of the suppurative process.

[Ultrastructural changes in the erythrocytes irradiated with ultraviolet light].

The ultrastructure of erythrocytes of donor blood and blood of patients suffering from kidney insufficiency was studied with the help of scanning and transmission electron microscopes before and after it was treated with ultraviolet light. It was concluded that after being treated with ultraviolet light, the ultrastructure of donor blood erythrocytes undergoes significant positive changes which are being characterized by normalization of the form of cells, decrease of associative ties between them, the cytoplasm content becomes more homogenous. There was a noticeable increase of a number of discocytes and a decreased number of associative ties between the cells after the patients' own blood was treated with ultraviolet light.

[The effect of ultraviolet irradiation of patients' blood on the morphofunctional status of erythrocytes].

The morphofunctional status of red blood cells was studied in patients with terminal renal failure associated with pyo-inflammatory complications treated by means of ultraviolet radiation of autologous blood. The authors have established that ultraviolet radiation of autologous blood results in the increase of the discocyte count and red blood cell activation, evidenced by the rise of the young red blood cell count, of the red blood cell population with marked activity of glucose 6-phosphate dehydrogenase, of the content of sulfhydryl groups, and by the increase of erythrocytic adhesion.

[Morphofunctional changes in blood cells irradiated with ultraviolet light].

Red cell and leukocyte morphology and function have been examined in donor blood UV irradiated in a flow closed circulation. The studies have revealed that a single UV irradiation enhances red cell resistance to chemical hemolysis, helps them acquire normal shape; besides, it improves leukocytic functional activity, that manifests by enhanced phosphatase activity and augmentation of the granulocyte phagocytic activity.

[Combined methods of extracorporeal detoxication in the treatment of severe surgical endotoxemia].

A combined method of treatment--flowing ultraviolet irradiation of autoblood with hemosorption or exchange plasmapheresis--was used in 52 patients with pyoseptic diseases. It was shown that inclusion of combined extracorporal detoxication in the complex treatment was followed by a pronounced clinical effect and correction of biochemical and physiological parameters.