Tissue microarray analysis of C-MYC oncogene copy number changes in larynx carcinoma.

Purpose Of The Study: Copy number changes and structural rearrangements of 8q in tumors from the head and neck region have been reported by numerous studies. To give better insights into the role of 8q abnormalities in larynx carcinoma, C-MYC copy number changes were studied in a large number of tumor materials.

Procedures: Fluorescent in situ hybridization with DNA locus-specific probe for C-MYC genewas applied on tissue microarrays presented by 863 larynx tumors.

Tissue microarray analysis of EGFR and HER2 oncogene copy number alterations in squamous cell carcinoma of the larynx.

Purpose: To evaluate EGFR and HER2 copy number changes and to assess their significance to tumor progression in a large group of patients with larynx cancer through the construction of a tissue microarray (TMA) consisting of 1,385 biopsies.

Methods: Fluorescent in situ hybridization (FISH) was applied to analyze the tumors. FISH was successful for EGFR in 1,080 (77.