Publications by authors named "Vesna Zuzel"
Article Synopsis
- Researchers studied ATP7B, a gene linked to platinum chemotherapy resistance in ovarian cancer, to find new treatment methods.
- In their experiments, they found that silencing ATP7B significantly reduced resistance to cisplatin, a common chemotherapy drug, leading to increased drug effectiveness in resistant cancer cells.
- When tested in live models, delivering ATP7B-targeted siRNA alongside cisplatin resulted in substantial tumor growth reduction and improved cancer cell death, suggesting a promising approach to overcoming drug resistance.
Human Cu-ATPases ATP7A and ATP7B maintain copper homeostasis through regulated trafficking between intracellular compartments. Inactivation of these transporters causes Menkes disease and Wilson disease, respectively. In Menkes disease, copper accumulates in kidneys and causes tubular damage, indicating that the renal ATP7B does not compensate for the loss of ATP7A function.
View Article and Find Full Text PDFThe human copper-transporting ATPases (Cu-ATPases) are essential for dietary copper uptake, normal development and function of the CNS, and regulation of copper homeostasis in the body. In a cell, Cu-ATPases maintain the intracellular concentration of copper by transporting copper into intracellular exocytic vesicles. In addition, these P-type ATPases mediate delivery of copper to copper-dependent enzymes in the secretory pathway and in specialized cell compartments such as secretory granules or melanosomes.
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