A J-shaped association between plasma testosterone and risk of ischemic arterial event in elderly men: the French 3C cohort study.

Objectives: Low plasma testosterone is associated with increased mortality in men. However, the relation between testosterone and cardiovascular disease is uncertain. We assessed the association of plasma sex hormones with the incidence of ischemic arterial disease (IAD) in elderly men.

Low plasma testosterone and elevated carotid intima-media thickness: importance of low-grade inflammation in elderly men.

Context And Objective: An inverse correlation between plasma testosterone levels and carotid intima-media thickness (IMT) has been reported in men. We investigated whether this association could be mediated or modified by traditional cardiovascular risk factors as well as inflammatory status.

Methods: In the Three-City population-based cohort study, 354 men aged 65 and over had available baseline data on hormones levels and carotid ultrasonography.

Increased thrombin generation among postmenopausal women using hormone therapy: importance of the route of estrogen administration and progestogens.

Objective: Increased thrombin generation has emerged as a new surrogate marker of venous thromboembolism. Using calibrated automated thrombography, we tested the influence of the route of estrogen administration and progestogens on thrombin generation among postmenopausal women using hormone therapy.

Methods: Baseline thrombin generation, together with clotting factors and inhibitors, was determined in plasma from 115 healthy postmenopausal women.