An open-label dose-response study of lymphocyte glutathione levels in healthy men and women receiving pressurized whey protein isolate supplements.

Background: High-pressure treatment of whey protein may increase digestibility and bioavailability of cysteine. The purpose of the study was to determine whether total lymphocyte glutathione (gamma-glutamyl-cysteinyl-glycine [GSH]) levels (oxidized+reduced) can be augmented from three different doses of pressurized whey protein supplements in a dose-dependent manner over a 2-week period.

Methods: Eighteen healthy males and 18 healthy females were randomized into three different groups, with 31 finishing the study.