Drug-induced Sweet's syndrome: A case/non-case study in the French pharmacovigilance database.

Aims: Sweet's syndrome is an acute febrile neutrophilic dermatosis first described in 1964 by Robert Douglas Sweet. The pathophysiological mechanism is not fully established; however, several cases of Sweet's syndrome have been reported following drug administration.

Methods: To investigate the existence of pharmacovigilance signals between drugs and the occurrence of Sweet's syndrome, we performed a case/non-case study on reports of 'acute febrile neutrophilic dermatosis' registered in the French pharmacovigilance database.

Adverse drug reactions in infants, children and adolescents exposed to antidepressants: a French pharmacovigilance study.

Purpose: Despite their frequent use in children and adolescents, the evidence for efficacy and safety of antidepressants (ATDs) in this population is scarce and off-label prescribing common. The aim of this study was to describe reported adverse drug reactions (ADRs) associated to ATDs over a 30-year period using the French Pharmacovigilance Database (FPVD).

Methods: We performed an analysis of ADRs registered in the FPVD from 1985 to 2016, occurred in children and adolescents receiving an ATD.

Methylprednisolone-related liver injury: A descriptive study using the French pharmacovigilance database.

Purpose: Hepatotoxicity associated with methylprednisolone (MP) is rarely reported in the literature. The aim of the present study was to review the characteristics of acute liver injury associated with intravenous (IV) or oral MP registered in the French pharmacovigilance database (FPD).

Methods: All cases with MP coded as suspected, concomitant, or interacting drug associated with liver injury as the adverse effect reported up to May 2016 were extracted from the FPD.

[Surveillance system on drug abuse: Interest of the French national OPPIDUM program of French addictovigilance network].

It is important to assess drug abuse liability in 'real life' using different surveillance systems. OPPIDUM ('Observation of illegal drugs and misuse of psychotropic medications') surveillance system anonymously collects information on drug abuse and dependence observed in patients recruited in specialized care centers dedicated to drug dependence. The aim of this article is to demonstrate the utility of OPPIDUM system using 2015 data.

Drug-induced Depression: a Case/Non Case Study in the French Pharmacovigilance Database.

Depression is a complex disorder with heterogeneous clinical anomalies whose neurobiological understanding still remains unclear. Medications have been implicated as potential causes of depression but for many of them, data are controversial. The present study aims to investigate association bet ween drugs and reports of depression.

Implementation of an automated signal detection method in the French pharmacovigilance database: a feasibility study.

Purpose: In France, early detection of adverse effects does not currently involve any automatic signal detection method. The present objective was to assess the feasibility and measure the potential benefit of the incorporation of an automatic signal detection tool (GPS(pH0)) in the French pharmacovigilance system.

Methods: GPS(pH0) was first applied to the data collected from 1 January 2000 to 31 December 2008 and then to the data collected from 1 January 2000 to 31 March 2009.