Enantiomeric separation of N-protected amino acids by non-aqueous capillary electrophoresis with dimeric forms of quinine and quinidine derivatives serving as chiral selectors.

A non-aqueous capillary electrophoretic method with quinine and tert.-butyl carbamoylated quinine as chiral selectors was developed previously for the enantioseparation of N-protected amino acids. This system was here applied as a screening tool for a fast evaluation of the chiral discrimination potential of six new dimeric forms of carbamoylated quinine and quinidine derivatives as chiral additives: 1,3-phenylene-bis(carbamoylated quinine), 1,6-hexamethylene-bis(carbamoylated quinine), 1,6-hexamethylene-bis(carbamoylated quinidine), trans-1,4-cyclohexylene-bis(carbamoylated quinine), trans-1,4-cyclohexylene-bis(carbamoylated-11-dodecylthio-dihydroquinine) and trans-1,4-cyclohexylene-bis(carbamoylated-11-dodecylsulfinyl-dihydroquinine).

Analysis of illicit amphetamine seizures by capillary zone electrophoresis.

Capillary zone electrophoresis was applied for the determination of amphetamine and related substances in seized drugs. A buffer made of 0.1 M phosphoric acid adjusted to pH 3.