Developmental epigenetic programming of adult germ cell death disease: Polycomb protein EZH2-miR-101 pathway.

Aim: The Developmental Origin of Health and Disease refers to the concept that early exposure to toxicants or nutritional imbalances during perinatal life induces changes that enhance the risk of developing noncommunicable diseases in adulthood. Patients/materials & methods: An experimental model with an adult chronic germ cell death phenotype resulting from exposure to a xenoestrogen was used.

Results: A reciprocal negative feedback loop involving decreased EZH2 protein level and increased miR-101 expression was identified.

In vitro fertilization versus conversion to intrauterine insemination in Bologna-criteria poor responders: how to decide which option?

Objective: To compare the continuation of in vitro fertilization (IVF) with the conversion to intrauterine insemination (IUI) in cases of suboptimal ovarian response in Bologna-criteria poor responders.

Design: Retrospective and multicenter comparative study.

Setting: Three academic fertility centers and a fertility private clinic.

[Male infertility due to azoospermia and in vitro fertilization assisted by ICSI. Findings based on a prospective study of our first 42 patients].

Introduction: Our experience of ICSI began in 1997. This study reviews our four-year experience based on 42 consecutive couples.

Material And Method: Between February 1997 and December 2000, 42 sterile couples due to male infertility were treated by ICSI.