The role of abnormal hypermethylation of the and promoters in implantation failures in IVF programs.

The objective of this study is to investigate the association between methylation levels of and promoters, clinical parameters, and implantation outcomes after fertilization-embryo transfer (IVT-ET) cycles in women with repeated implantation failures and tubal infertility. Endometrium samples were collected from 34 women during implantation window before IVF-ET cycle to assess methylation status of and promoters using bisulfite sequencing. All participants had a tubal factor of infertility and at least two implantation failures in the anamnesis.