Deletion of the Ca Channel Subunit αδ3 Differentially Affects Ca2.1 and Ca2.2 Currents in Cultured Spiral Ganglion Neurons Before and After the Onset of Hearing.

Voltage-gated Ca channels are composed of a pore-forming α subunit and auxiliary β and αδ subunits, which modulate Ca current properties and channel trafficking. So far, the partial redundancy and specificity of α for αδ subunits in the CNS have remained largely elusive. Mature spiral ganglion (SG) neurons express αδ subunit isoforms 1, 2, and 3 and multiple Ca channel subtypes.