Lymphocytes from healthy humans and pigs were tested for their viability after being exposed to the mycotoxins fumonisin B1 (FB1) and ochratoxin A (OTA), known for their immunosuppressive and carcinogenic properties.
The study aimed to explore the effectiveness of pig lymphocytes in the MTT cytotoxicity test as a more accessible alternative to human lymphocytes and assess the toxic effects of the mycotoxins both individually and in combination.
Results indicated that exposure to these toxins led to decreased lymphocyte viability over time, with FB1 being less toxic than OTA, and a synergistic effect was observed when both toxins were combined, particularly affecting pig lymphocytes more severely.