Publications by authors named "Veronika Melnik"
Article Synopsis
- Glucagon signaling is crucial for keeping blood sugar levels stable in mammals, and the ARRDC4 protein plays an important role in this process.
- Research shows that mice without the ARRDC4 protein struggle with glucagon responses and gluconeogenesis, leading to lower blood sugar after fasting.
- ARRDC4 also interacts with the glucagon receptor and its expression is influenced by insulin, highlighting its key role in regulating glucose metabolism and connecting insulin and glucagon pathways in the liver.
Objective: This study aimed to assess whether continuous glucose monitor use in type 2 diabetes mellitus in pregnancy is associated with improved perinatal outcomes.
Data Sources: We searched Ovid MEDLINE, Scopus, ClinicalTrials.gov, and Cochrane library from inception through May 9, 2022.
Amyotrophic lateral sclerosis (ALS) is characterized by motor neuron degeneration accompanied by aberrant accumulation and loss of function of the RNA-binding protein TDP43. Thus far, it remains unresolved to what extent TDP43 loss of function directly contributes to motor system dysfunction. Here, we employed gene editing to find whether the mouse ortholog of the TDP43-regulated gene STMN2 has an important function in maintaining the motor system.
View Article and Find Full Text PDFInsulin action in the liver is critical for glucose homeostasis through regulation of glycogen synthesis and glucose output. Arrestin domain-containing 3 () is a member of the α-arrestin family previously linked to human obesity. Here, we show that is differentially regulated by insulin in vivo in mice undergoing euglycemic-hyperinsulinemic clamps, being highly up-regulated in liver and down-regulated in muscle and fat.
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