Publications by authors named "Veronika Hanosova"
J Phys Chem B
September 2008
Article Synopsis
- The hepatitis delta virus (HDV) ribozyme contains a crucial RNA motif, with the nucleotide C75 playing an essential role in self-cleavage, though its exact function sparked ongoing debate.
- Structural studies indicate that C75 may serve as a general base during catalysis, helping to deprotonate a key nucleophile, while magnesium ions may act in a protonating capacity.
- Recent quantum chemical/molecular mechanical calculations support the idea that C75 can indeed function as a general base, with a calculated reaction energy barrier that fits well with experimental findings, suggesting magnesium also plays a role as a Lewis acid.
