, Encoding the Hyperosmotic Stress Protein Glycerol-3-phosphate Dehydrogenase, Disrupts Osmoadaptation in .

The genome of the osmophilic , unlike that of the osmotolerant , contains only the , but not the , glycerol 3-phosphate dehydrogenase gene. Here, we studied transcriptomic changes of (reference strain and Δ gene deletion mutant) and (reference strain and expressing mutant) elicited by high osmolarity. showed a canonic hyperosmotic stress response characterized by the upregulation of the trehalose and glycerol metabolism genes (including ), as well as the genes of the high-osmolarity glycerol (HOG) map kinase pathway.

Species-specific effects of the introduction of Aspergillus nidulans gfdB in osmophilic aspergilli.

Industrial fungi need a strong environmental stress tolerance to ensure acceptable efficiency and yields. Previous studies shed light on the important role that Aspergillus nidulans gfdB, putatively encoding a NAD-dependent glycerol-3-phosphate dehydrogenase, plays in the oxidative and cell wall integrity stress tolerance of this filamentous fungus model organism. The insertion of A.