Publications by authors named "Veronika Anita Deak"
Article Synopsis
- GSKIP is a cytosolic scaffolding protein that interacts with PKA and GSK3β, and both interactions are essential for regulating β-catenin and Wnt signaling.
- GSKIP helps stabilize β-catenin by promoting its phosphorylation at Ser-675 and preventing its degradation by sequestering GSK3β away from the destruction complex.
- Unlike other AKAPs like AKAP220, GSKIP specifically influences Wnt signaling, which is crucial for various biological processes and is linked to several diseases.
Article Synopsis
- A-kinase anchoring proteins (AKAPs) are diverse proteins that bind to protein kinase A (PKA), with GSK3β interaction protein (GSKIP) being one example that also interacts directly with GSK3β.
- GSKIP-deficient mice were created, and this absence led to lethal outcomes at birth, marked by conditions such as cyanosis and respiratory distress in embryos.
- The study revealed that GSKIP plays a vital role in regulating GSK3β signaling, particularly in the fusion of the palatal shelves during development, indicating its importance in embryonic growth and health.
The second messenger cyclic adenosine monophosphate (cAMP) can bind and activate protein kinase A (PKA). The cAMP/PKA system is ubiquitous and involved in a wide array of biological processes and therefore requires tight spatial and temporal regulation. Important components of the safeguard system are the A-kinase anchoring proteins (AKAPs), a heterogeneous family of scaffolding proteins defined by its ability to directly bind PKA.
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