Antibacterial Thiopeptide GE2270-Congeners from .

Thiopeptides are macrocyclic natural products with potent bioactivity. Nine new natural thiopeptides (1−9) were obtained from a Nonomuraea jiangxiensis isolated from a terrestrial soil sample collected in Singapore. Even though some of these compounds were previously synthesized or isolated from engineered strains, herein we report the unprecedented isolation of these thiopeptides from a native Nonomuraea jiangxiensis.

Antibacterial Spirotetronate Polyketides from an sp. Strain A30804.

Large scale cultivation and chemical investigation of an extract obtained from sp. resulted in the identification of six previously undescribed spirotetronates (pyrrolosporin B and decatromicins C-G; -), along with six known congeners, namely decatromicins A-B (-), BE-45722B-D (-), and pyrrolosporin A (). The chemical structures of compounds - were characterized via comparison with previously reported data and analysis of 1D/2D NMR and MS data.