Publications by authors named "Veronica Veksler"
Article Synopsis
- HIV-associated neurocognitive impairment (HIV-NCI) affects a significant percentage of people with HIV, even those receiving effective antiretroviral therapy, indicating that the condition remains a serious concern.
- The study identified that the movement of specific immune cells (CD14+CD16+ monocytes) across the blood-brain barrier contributes to cognitive issues by damaging neurons and activating harmful responses in the brain.
- It was found that people with HIV-NCI have increased transmigration of these monocytes compared to those with normal cognition, and factors like hypertension and diabetes may influence this relationship, highlighting the need for targeted treatments.
The COVID-19 pandemic has caused more than three million deaths globally. The severity of the disease is characterized, in part, by a dysregulated immune response. CD16+ monocytes are innate immune cells involved in inflammatory responses to viral infections, and tissue repair, among other functions.
View Article and Find Full Text PDFAmphiphilicity in ɑ-helical antimicrobial peptides (AMPs) is recognized as a signature of potential membrane activity. Some AMPs are also strongly immunomodulatory: LL37-DNA complexes potently amplify Toll-like receptor 9 (TLR9) activation in immune cells and exacerbate autoimmune diseases. The rules governing this proinflammatory activity of AMPs are unknown.
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