Publications by authors named "Veronica Sule"

The purpose of this study was to compare the wear resistance of light-cure resin luting cements for veneers with that of other luting materials investigated in earlier studies. An Alabama wear-testing machine was used to measure the wear resistance of four recent light-cure resin luting cements for veneers (G-Cem Veneer; Panavia V5 LC; RelyX Veneer Cement; and Vario-link Esthetic LC). The volume loss ranged from 0.

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Background: A fundamental ethical issue in African genomics research is how socio-cultural factors impact perspectives, acceptance, and utility of genomic information, especially in stigmatizing conditions like orofacial clefts (OFCs). Previous research has shown that gatekeepers (e.g.

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Background: Inadequate knowledge among health care providers (HCPs) and parents of affected children limits the understanding and utility of secondary genetic findings (SFs) in under-represented populations in genomics research. SFs arise from deep DNA sequencing done for research or diagnostic purposes and may burden patients and their families despite their potential health importance. This study aims to evaluate the perspective of both groups regarding SFs and their choices in the return of results from genetic testing in the context of orofacial clefts.

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Introduction: The frequency and implications of secondary findings (SFs) from genomic testing data have been extensively researched. However, little is known about the frequency or reporting of SFs in Africans, who are underrepresented in large-scale population genomic studies. The availability of data from the first whole-genome sequencing for orofacial clefts in an African population motivated this investigation.

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Article Synopsis
  • The study investigates damaging mutations in the human genome that may contribute to nonsyndromic cleft lip with or without cleft palate (nsCL ± P), focusing on high-impact mutations in African and Brazilian cohorts.* -
  • Researchers utilized next-generation sequencing (NGS) and whole-exome sequencing to identify pathogenic variants and discovered several damaging mutations in a gene related to cell adhesion, which has a link to cleft palate in mice.* -
  • The findings highlight the significance of the gene encoding AFADIN in the risk for nsCL ± P in humans and emphasize the effectiveness of combining NGS with computational analysis to better understand this condition's genetic basis.*
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