Publications by authors named "Veronica S Montero"
Purpose: Transcutaneous spinal cord stimulation (TSCS) is a novel neuromodulation modality developed to promote functional restoration in patients with neurological injury or disease. Previous pilot data suggest that lower urinary tract dysfunction (LUTD) due to stroke may be partially alleviated by TSCS. In this study, we examine the mechanism of this effect by evaluating bladder-related brain activity in patients before and after TSCS therapy and comparing it to healthy volunteers.
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View Article and Find Full Text PDFMechanisms leading to low platelet count in immune thrombocytopenia (ITP) involves both decreased production and increased destruction of platelet. However, the contribution of these pathologic mechanisms to clinical outcome of individual patients is uncertain. Here we evaluated different pathogenic mechanisms including in vitro megakaryopoiesis, platelet/megakaryocyte (MK) desialylation and MK apoptosis, and compared these effects with thrombopoyesis and platelet apoptosis in the same cohort of ITP patients.
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- The study aims to understand the reasons behind low platelet counts in immune thrombocytopenia (ITP) by examining how ITP plasma affects proplatelet formation (PPF) in healthy megakaryocytes.
- Patient plasma was found to inhibit PPF in a dose-dependent manner, altering the structure of proplatelets, but increased megakaryocyte apoptosis was not responsible for this impairment.
- The research indicates that auto-antibodies in ITP plasma disrupt normal thrombopoiesis, particularly through their effects on integrins crucial for platelet formation, highlighting new insights into the mechanisms behind platelet count reduction in ITP.