Publications by authors named "Veronica N Natale"
Article Synopsis
- The study compared the long-term effectiveness of standard antithrombotic treatment versus half-dose direct oral anticoagulation (DOAC) following Watchman implantation in patients.
- A total of 555 patients were analyzed, with results showing that device-related thrombosis (DRT) occurred only in patients receiving standard antithrombotic strategy, while the half-dose DOAC group had a significantly lower risk of nonprocedural major bleeding.
- The findings concluded that half-dose DOAC significantly lowered the risks of DRT, thromboembolic events, and major bleeding compared to the standard strategy, highlighting its potential as a more effective treatment option post-implantation.
Aims: We evaluated the efficacy of an ablation strategy empirically targeting pulmonary veins (PVs) and posterior wall (PW) and the prevalence and clinical impact of extrapulmonary trigger inducibility and ablation in a large cohort of patients with persistent atrial fibrillation (PerAF).
Methods And Results: A total of 1803 PerAF patients were prospectively enrolled. All patients underwent pulmonary vein antrum isolation (PVAI) extended to the entire PW.
Radiofrequency Energy Applications Targeting Significant Residual Leaks After Watchman Implantation: A Prospective, Multicenter Experience.
JACC Clin Electrophysiol
December 2021
Article Synopsis
- * A total of 43 patients aged around 75 years with notable leaks after the procedure were treated using RF applications, achieving a median leak size reduction from 5 mm to nearly 0 mm, and had a low complication rate of just 2.3%.
- * The findings suggest that RF techniques can effectively promote tissue healing and LAA sealing after Watchman procedures, ultimately reducing the risk of future complications related to leaks.
Article Synopsis
- Atrioesophageal fistula (AEF) is a serious complication of atrial fibrillation ablation, with a median symptom onset of 21 days post-procedure and a high mortality rate of 59.3%.
- Most patients (75%) showed neurological issues, and those evaluated at walk-in clinics faced longer delays in treatment compared to those seen by specialists.
- Early recognition of symptoms, understanding diagnostic challenges, and timely coordination with electrophysiologists are crucial to improve outcomes and minimize mortality rates associated with AEF.
Objectives: This study sought to report the incidence of device-related thrombosis (DRT) and thromboembolic (TE) events when an alternative to clopidogrel is prescribed in loss-of-function (LOF) allele carriers of the cytochrome P450 2C19 (CYP2C19) gene.
Background: LOF polymorphisms of the CYP2C19 gene are associated with reduced hepatic bioactivation of clopidogrel.
Methods: A total of 1,002 Watchman patients were included.
Use of a Novel Septal Occluder Device for Left Atrial Appendage Closure in Patients With Postsurgical and Postlariat Leaks or Anatomies Unsuitable for Conventional Percutaneous Occlusion.
Circ Cardiovasc Interv
October 2020
Background: Interventional therapies aiming at excluding the left atrial appendage (LAA) from systemic circulation have been established as a valid alternative to oral anticoagulation in patients at high thromboembolic risk. However, their efficacy on stroke prophylaxis may be compromised owing to incomplete LAA closure. Additionally, the need for an alternative thromboembolic prevention may remain unmet in patients with contraindications to oral anticoagulation whose appendage anatomy is unsuitable for some conventional devices commercially available.
View Article and Find Full Text PDFObjectives: The aim of this study was to assess the feasibility and efficacy of transcatheter leak closure with detachable coils in patients with incomplete left atrial appendage (LAA) closure.
Background: Incomplete LAA closure is common after interventional therapies targeting the LAA, potentially hindering effective thromboembolic prevention. Detachable coils have found a wide range of applications for transcatheter vascular occlusion and embolization procedures.