Publications by authors named "Veronica Maggi"
Study Objective: To evaluate recurrence rate and pattern in apparently early-stage endometrial cancer (EC) treated with minimally invasive surgery (MIS) and compare it to the "historical" populations treated by laparotomy. Secondary outcomes were to establish if, among MIS recurrent patients, intermediate-high/high-risk patients presented the same recurrence pattern compared to those at low/intermediate-risk and to evaluate time to first recurrence (TTR) of the study population.
Design: Multicenter retrospective observational study.
Background: The rate of concurrent endometrial cancer (EC) in atypical endometrial hyperplasia (AEH) can be as high as 40%. Some patient characteristics showed associations with this occurrence. However, their real predictive power with related validation has yet to be discovered.
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- Oncovascular surgery, which involves removing major blood vessels affected by cancer, is crucial for achieving complete removal of tumors in advanced ovarian cancer patients.
- A review of patient cases at Verona University showed that five patients had successful major vascular resections, with all having preoperative identification of vascular involvement and obtaining R0 status (no visible cancer remaining).
- The literature review found a total of 12 cases of major vessel resections in ovarian cancer, with a notable percentage experiencing postoperative complications, yet a majority remained disease-free at their last follow-up.
The development of personalized therapies for ovarian carcinoma patients is still hampered by several limitations, mainly the difficulty of predicting patients' responses to chemotherapy in tumor cells isolated from peritoneal fluids. The main reason for the low predictive power of in vitro assays is related to the modification of the cancer cells' phenotype induced by the culture conditions, which results in changes to the activation state and drug sensitivity of tumor cells compared to their in vivo properties. We have defined the optimal culture conditions to set up a prognostic test to predict high-grade serous ovarian carcinoma (HGSOC) patients' responses to platinum chemotherapy.
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