Azole resistance in the fungus Aspergillus fumigatus is becoming more common worldwide, affecting patients even without prior exposure to the medication.
Specific mutations (TR34 L98H and TR46 Y121F T289A) linked to this resistance have been seen across various continents, including Europe, Asia, and Australia.
Recent findings confirm the presence of these mutations in A. fumigatus samples collected from institutions in the United States, alongside information about other resistance-related mutations and azole MIC levels.