Novel techniques for drug loading quantification in mesoporous SBA-15 using chemometric-assisted UV and FT-IR data.

Albendazole is a crystalline drug that is poorly soluble in water, thus the dissolution rate in gastrointestinal fluids is limited. Mesoporous materials loaded with poorly water-soluble drugs become an interesting strategy to increase their solubility/dissolution rate as the drug state changes from crystalline to amorphous. In order to determine the drug loading content into mesoporous materials analytical methods such as elemental analysis, UV and HPLC are commonly used.

Nebulization of a polyelectrolyte-drug system for systemic hypertension treatment.

Hypertension is a chronic pathology where blood pressure levels are continuously high, causing cardiac, renal, cerebral, and vascular damage leading to early morbi-mortality. This illness is the main risk factor for cardiovascular diseases and the main cause of atrial fibrillation. Atenolol (AT) is a β-1 blocker drug useful for antihypertension and antiarrhythmic treatments.

Cleaner and sustainable processes for extracting phenolic compounds from bio-waste.

The frequent environment-unfriendly treatments of agro-industrial bio-wastes cause severe pollution through air pollution and through residual effluents and hazardous solid waste. These bio-wastes can contain phenolic compounds, forms of phenolic acids and flavonoids in plants. They are however the most abundant class of many phytochemicals and have been given great interest due to their health advantage and high economic value.

Development of a Carrier-Free Dry Powder Ofloxacin Formulation With Enhanced Aerosolization Properties.

Tuberculosis (TB) is a serious infectious disease that affects more than new 10 million patients each year. Many of these cases are resistant to first-line drugs so second-line ones, like fluoroquinolones, need to be incorporated into the therapeutic. Ofloxacin (OF) is a fluoroquinolone which demonstrates high antibiotic activity against the bacteria that causes TB (M.

Synthesis and characterization of mesoporous SBA-15 and SBA-16 as carriers to improve albendazole dissolution rate.

Albendazole (ABZ, anti-parasitic active pharmaceutical ingredient) is a crystalline low water-soluble drug, thus the dissolution rate in gastrointestinal fluids is limited. Consequently, the improvement of the water solubility and dissolution rate of ABZ implies a great challenge for a more efficient treatment of hydatidosis. In this context, SBA-15 and SBA-16 ordered mesoporous silica materials were synthetized and loaded with ABZ.

Optimized aqueous extracts of maqui () suitable for powder production.

The aim of this work was to obtain powders rich in bioactive compounds from maqui berry aqueous extracts by spray drying. First, the process parameters of the maqui aqueous extraction were optimized. The optimal operating conditions were found using an experimental Box-Behnken design with three factors: solvent/fruit ratio (2:1, 3.

Carrier free indomethacin microparticles for dry powder inhalation.

The present studies were designed to evaluate inhalatory microparticles carrying indomethacin (IN) for potential local (specific and non-specific bronchial inflammatory asthma responses) and systemic treatments (joint inflammation, rheumatoid arthritis and osteoarthritis pain) by optimizing microparticle properties, characterizing their lung deposition, drug release, evaluating cytotoxicity and also pharmacological effect in vitro. The acidic groups of IN were complexed with the cationic groups of the polyelectrolyte polylysine in order to increase the drug water compatibility. The polylysine/indomethacin ratio was fixed and the pH was adjusted in different formulations.

A Review on Influence of Spray Drying Process Parameters on the Production of Medicinal Plant Powders.

Medicinal plants are used by 80% of the world population as primary health care and the phytomedicine market is growing exponentially. Currently, the production of phytopharmaceuticals with proper efficacy, safety and consistent quality constitutes a relevant challenge. The dried dosage forms of medicinal plants are preferred than liquid presentations because of their higher stability.

Impact of feed counterion addition and cyclone type on aerodynamic behavior of alginic-atenolol microparticles produced by spray drying.

The inhalatory route has emerged as an interesting non-invasive alternative for drug delivery. This allows both pulmonary (local) and systemic treatments (via alveolar absorption). Further advantages in terms of stability, dose and patient preference have often lead researchers to focus on dry powder inhaler delivery systems.

Formulation and Characterization of Polysaccharide Microparticles for Pulmonary Delivery of Sodium Cromoglycate.

Sodium cromoglycate (SC) is an antiasthmatic and antiallergenic drug commonly used for chronic inhalation therapy; however, many daily intakes are required due to the fast drug clearance from airways. For these reasons, SC polymeric particles for inhalatory administration with adequate aerosolization and mucoadhesive properties were designed to prolong the drug residence time in the site of action. Sodium carboxymethylcellulose (CMCNa), sodium hyaluronate, and sodium alginate were selected to co-process SC by spray drying.

Design and in vitro characterization of ivermectin nanocrystals liquid formulation based on a top-down approach.

The aim of this study was to develop ivermectin (IVM) nanosuspensions (NSs) to improve the dissolution rate of this poorly water-soluble drug. Different NSs combining different stabilizers, i.e.

New alginic acid-atenolol microparticles for inhalatory drug targeting.

The inhalatory route allows drug delivery for local or systemic treatments in a noninvasively way. The current tendency of inhalable systems is oriented to dry powder inhalers due to their advantages in terms of stability and efficiency. In this work, microparticles of atenolol (AT, basic antihypertensive drug) and alginic acid (AA, acid biocompatible polyelectrolyte) were obtained by spray drying.

Valeriana officinalis Dry Plant Extract for Direct Compression: Preparation and Characterization.

Valeriana officinalis L. (Valerianaceae) is one of the most widely used plants for the treatment of anxiety and insomnia. Usually dry plant extracts, including V.

Effect of temperature on the release of hexadecane from soil by thermal treatment.

A natural organic soil (2.5% of total organic carbon) was artificially contaminated with hexadecane, and thermally treated under an inert medium up to different final temperatures (150-800 degrees C) for 30 min to simulate ex situ thermal process conditions. The experiments were conducted using a complete organic soil, instead of the clays or isolated soil fractions that are commonly used.

Thermal treatment of soils contaminated with gas oil: influence of soil composition and treatment temperature.

Samples of two soils containing different organic matter contents, neat or contaminated with gas oil (diesel fuel oil) at 2.5 wt.% were heated from room temperature to different final temperatures (200-900 degrees C).