Publications by authors named "Veronica Aedo"
Adoptive cell therapy (ACT) using ex vivo-expanded tumor-infiltrating lymphocytes (TILs) can eliminate or shrink metastatic melanoma, but its long-term efficacy remains limited to a fraction of patients. Using longitudinal samples from 13 patients with metastatic melanoma treated with TIL-ACT in a phase 1 clinical study, we interrogated cellular states within the tumor microenvironment (TME) and their interactions. We performed bulk and single-cell RNA sequencing, whole-exome sequencing, and spatial proteomic analyses in pre- and post-ACT tumor tissues, finding that ACT responders exhibited higher basal tumor cell-intrinsic immunogenicity and mutational burden.
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- The OpTAT study focuses on optimizing oral targeted anticancer therapies to enhance patient care through an interprofessional medication adherence program and monitoring PKI plasma concentrations.
- The study includes a randomized program involving motivational interviews with pharmacists and the use of electronic monitors for drug delivery, alongside comprehensive data collection for pharmacokinetic analysis.
- By analyzing medication adherence and PKI pharmacokinetics, the study aims to identify factors influencing treatment response and improve overall patient outcomes.
The year 2018 has been incredibly prolific regarding novelties. Several studies have given impressive results and offer new anticancer perspectives. Immunotherapy is gaining more and more place defining a new standard of care for different types of cancer.
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