To the Editor: Early school start times in middle and high schools have profound implications for children and teens.

Unlabelled: This letter to the editor aims to prompt medical students, residents, and sleep medicine fellows to actively support the implementation of delayed school start times in middle and high schools, considering the significant impact it holds for children and adolescents. During puberty, research has demonstrated that circadian changes result in a sleep-phase delay among adolescents, leading them to sleep and wake up later compared to other age groups. This, coupled with early school start times, contributes to sleep deprivation within this patient population, increasing the likelihood of drowsy driving accidents, mental health problems, academic underperformance, and a predisposition to chronic illnesses like diabetes mellitus and hypertension.

How Does It Work? Unraveling the Mysteries by Which Empagliflozin Helps Diabetic and Non-diabetic Patients With Heart Failure.

In patients with heart failure, empagliflozin offers significant cardiovascular benefits. However, its exact mode of action is unknown. Understanding the way by which empagliflozin works in heart failure may uncover additional therapeutic targets or identify other classes of drugs that may be useful to clinicians and patients.

The New Kid on the Block: The Mechanisms of Action of Hyperleptinemia in Coronary Artery Disease and Atherosclerosis.

Leptin is an adipocytokine that consists of 167 amino acids. It functions as a regulator of hunger and energy expenditure. Leptin loses its ability to carry out its physiological function at high serum levels, and many studies have associated this loss of function with the development of coronary artery disease (CAD).

The Efficacy of Herbal Supplements and Nutraceuticals for Prevention of Migraine: Can They Help?

Migraine is a common neurological disorder associated with or without aura. Although the pathophysiology of migraine is not very well understood, pro-inflammatory cytokines and oxidative stress biomarkers are found to be increased in migraine. Multiple studies have been done to see if alternative medicine such as herbal supplements and nutraceuticals are effective in the prevention and treatment of migraine headaches.