Modelling ponatinib resistance in tyrosine kinase inhibitor-naïve and dasatinib resistant + cell lines.

TKI resistance remains a major impediment to successful treatment of CML. In this study, we investigated the emerging modes of ponatinib resistance in TKI-naïve and dasatinib resistant + cell lines. To investigate potential resistance mechanisms, ponatinib resistance was generated in + cell-lines by long-term exposure to increasing concentrations of ponatinib.