Publications by authors named "Verger E"
Article Synopsis
- A significant increase in food consumption outside the home is noted, impacting individual diets and health negatively, with limited data on this trend due to a lack of dietary surveys in certain regions.
- The study aimed to create and test two survey modules (one long and one short) in Burkina Faso and Vietnam to measure food consumed away from home in relation to regular Household Consumption and Expenditure Surveys.
- Although the modules showed good agreement with 24-hour dietary recalls (over 77% accuracy), they underestimated energy intake and overestimated spending on food consumed outside the home, indicating a need for better tools to assess these dietary habits globally.
Dietary diversity is a crucial component of healthy eating patterns because it ensures nutritional adequacy. Yet, concerns have been raised about the potential risks of its increase, which may reflect excessive consumption of unhealthy foods and higher obesity or cardiometabolic risk, particularly in high-income countries. However, the links between dietary diversity and different health outcomes remain inconclusive because of methodological differences in assessing dietary diversity.
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- Cerebral venous sinus thrombosis (CVST) is a rare type of stroke linked to brain injury, and the JAK2V617F mutation is associated with worse outcomes for patients with CVST.
- In a study using mice, researchers found that those with the JAK2V617F mutation experienced more severe symptoms, including higher rates of intracranial hemorrhages and mortality, compared to normal mice.
- Both mouse models and human cases showed that JAK2V617F-positive individuals had increased inflammation and thrombotic issues, contributing to poorer clinical outcomes after CVST.
Article Synopsis
- The study compares the clinical characteristics of primary myelofibrosis (PMF) and secondary myelofibrosis (SMF), highlighting key differences in patient presentation and symptoms.
- It explores the molecular landscape of both conditions, analyzing genetic mutations and other molecular factors that may influence the disease.
- The research also focuses on prognosis scoring systems, assessing how well they predict outcomes and survival rates for patients with PMF and SMF.
Article Synopsis
- - The study validated the Minimum Dietary Diversity for Women of Reproductive Age (MDD-W) as a measure of micronutrient adequacy for pregnant women in low- and middle-income countries (LMICs), addressing a gap in research for this specific group.
- - Researchers analyzed data from 4 LMICs (Bangladesh, Burkina Faso, India, and Nepal) with 4,909 participants to evaluate the relationship between food group diversity (measured by Women's Dietary Diversity Score - WDDS-10) and micronutrient adequacy (MPA).
- - Results indicated that a threshold of 5 or more food groups significantly predicted adequate micronutrient intake among pregnant women, showing strong sensitivity and specificity, suggesting
Article Synopsis
- Current risk scores for thrombotic events in myeloproliferative neoplasms (MPN) fail to differentiate between arterial and venous thrombosis, even though they have different causes and implications.
- A new score called ARTS, which considers factors like prior arterial thrombosis, age over 60, cardiovascular issues, and specific gene mutations, effectively stratifies patients into low- and high-risk groups for arterial thrombosis.
- Conversely, the VEnous Thrombosis Score (VETS), which only looks at prior venous thrombosis and JAK2 mutations, does not perform well, highlighting the need for better venous risk assessments that address its complexity.
Healthy diet and dietary diversity have been associated with healthy ageing. Several scores have been developed to assess dietary diversity or healthy diets in epidemiological studies, but they are not adapted to be used in the context of preventive nutrition interventions. This study aimed to develop an occurrence-based healthy dietary diversity (ORCHID) score easy to implement in the field and to validate it using dietary data from older participants in the latest French food consumption survey (INCA3).
View Article and Find Full Text PDFPurpose: Recent global-scale analysis showed the extent of inequality in terms of carbon emissions related to overall consumption, with richer households emitting significantly more greenhouse gases than poorer ones. While socio-economic status is a known determinant of food consumption, and despite the urgent need to move towards more sustainable diets, very few studies have explored socio-economic differences regarding the environmental impacts of diets. The objective of the present study was to compare the environmental impacts of French adults' diets according to food insecurity (FI) status and income level.
View Article and Find Full Text PDFThis is the protocol for a evidence and gap map. The main objective of this evidence and gap map is to provide access to a systematic overview of available indicators for diet-related consumer behaviours relevant to LMICs, to support policy makers and researchers to develop, monitor and revise food policies and programmes to leverage food systems transformations for healthier and more sustainable diets.
View Article and Find Full Text PDFBackground: Diet and physical activity are key components of healthy aging. Current interventions that promote healthy eating and physical activity among the elderly have limitations and evidence of French interventions' effectiveness is lacking. We aim to assess (i) the effectiveness of a combined diet/physical activity intervention (the "ALAPAGE" program) on older peoples' eating behaviors, physical activity and fitness levels, quality of life, and feelings of loneliness; (ii) the intervention's process and (iii) its cost effectiveness.
View Article and Find Full Text PDFIn the context of studies on the effects of agricultural production diversity, there are debates in the scientific community as to the level of diversification appropriate for improving dietary diversity. In Tunisia, agriculture is a strategic sector for the economy and a critical pillar of its food sovereignty. Using instrumental variable methods to account for endogeneity, we have estimated the association between agricultural production diversity and women's dietary diversity among smallholder farming households in the Sidi Bouzid governorate (central Tunisia).
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- The study investigates the transformation of chronic myeloproliferative neoplasms (MPN) to leukemia, highlighting TP53 mutations as a crucial factor, though their proliferation advantage requires a selection process.
- MDM2 inhibitors, which can protect normal p53 from degradation, show potential in treating TP53-mutated cells, but their effects in this context are not well-studied until now.
- The research reveals that TP53 mutations typically occur late in MPN development, predominantly within the driver clone, and it introduces an in vitro test that can predict the emergence of TP53-mutated cells in response to MDM2 inhibitors.
Tailored dietary counseling could be specifically efficient during pregnancy, a period accompanied by a rise in nutrition awareness, but little is known about the expectations of pregnant women in this regard. We studied these expectations regarding tailored dietary advice in French women during their pregnancy, as well as their motivations and the perceived barriers and enablers. In French pregnant women, we evaluated the perceptions of tailored dietary advice provided by stepwise dietary counseling based on three types of dietary changes, consisting of: (1) a modification of the amounts consumed, (2) substitutions within the food subgroups, and (3) substitutions between food subgroups.
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- Auger electron-emitters, particularly technetium-99m, show promise for targeted radionuclide therapy in breast cancer treatment, though its therapeutic potential needs more exploration.
- Researchers utilized engineered breast cancer cells (MDA-MB-231.hNIS-GFP) to study the uptake and effects of technetium-99m, measuring its ability to cause DNA damage and impact cell survival.
- Findings indicate that technetium-99m can significantly damage DNA and reduce cell survival only when internalized, suggesting it has potential applications for both imaging and therapy in oncology.
Article Synopsis
- * They found that low erythropoietin levels (≤3.3 mUI/ml) and JAK2 mutations had similar positive predictive values for identifying true polycythemia, around 90% for both tests.
- * Notably, very low erythropoietin levels (≤1.99 mUI/ml) were 100% predictive for diagnosing polycythemia vera, suggesting a need to rethink how erythropoietin is used in diagnostic criteria for this disease.
Introduction: The biological consequences of absorbed radiation doses are ill-defined for radiopharmaceuticals, unlike for external beam radiotherapy (EBRT). A reliable assay that assesses the biological consequences of any radionuclide is much needed. Here, we evaluated the cell-free plasmid DNA assay to determine the relative biological effects of radionuclides such as Auger electron-emitting [Ga]GaCl or [In]InCl compared to EBRT.
View Article and Find Full Text PDFDietary diversity has long been recognized as a key component of diet quality and many dietary diversity indicators (DDIs) have been developed. This systematic scoping review aimed to present a comprehensive inventory of DDIs and summarize evidence linking DDIs and dietary adequacy or health outcomes in adolescents and adults. Two search strategies were developed to identify peer-reviewed articles published in English up until June 2018 and were applied to Medline, Web of Science, and Scopus.
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- The study looked at how different gene mutations affect the health of people with myelofibrosis, a type of blood disease.
- Researchers analyzed 479 patients and grouped them based on specific mutations to see how these groups relate to worsening conditions or death.
- They found that mutations in certain genes like TP53 and high-risk genes made it more likely for patients to get worse or die, while a mutation in the ASXL1 gene alone didn’t have a significant negative impact.
Activation of the P53 pathway through inhibition of MDM2 using nutlins has shown clinical promise in the treatment of solid tumors and hematologic malignancies. There is concern, however, that nutlin therapy might stimulate the emergence or expansion of TP53-mutated subclones. We recently published the results of a phase 1 trial of idasanutlin in patients with polycythemia vera (PV) that revealed tolerability and clinical activity.
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- Interferon α (IFNα) is commonly used to treat myeloproliferative neoplasms (MPNs), but it rarely completely eliminates the disease.* -
- This study found that arsenic trioxide (ATO) significantly enhances the growth-suppressing effects of IFNα on JAK2V617F-driven hematopoietic cells by targeting a key gene called PML.* -
- The combination of IFNα and ATO in a mouse model of MPN led to accelerated and improved treatment responses, suggesting that this combo could be highly effective in clinical settings, even when the PML gene is intact.*
Article Synopsis
- * A study involving 80 MPN-SVT patients over an 11-year median follow-up found that 13% experienced severe hematologic outcomes, linked to higher JAK2 mutation levels and other genetic mutations.
- * High-risk patients, making up 29% of the cohort and showing significant molecular risk factors, had poorer survival rates, suggesting the need for targeted therapy to prevent disease progression.
Article Synopsis
- - The development of myeloproliferative neoplasms (MPNs) is linked to specific gene mutations in JAK2, MPL, or CALR, which are critical for diagnosis according to WHO standards.
- - In a study involving 1382 patients, rare and unexpected genetic profiles emerged, leading to challenges in accurately diagnosing MPNs due to mixed mutations and the need for additional genetic testing.
- - The findings highlight the importance of confirming mutations through direct Sanger sequencing and considering germline DNA alongside next-generation sequencing (NGS) for accurate interpretation and treatment decisions.