Pathogenic Variants Resulting in Dural Based Fibroinflammatory Mass Lesions and H Syndrome Treated With Cobimetinib: A Case Report.

Objectives: Pathogenic variants are known to cause autosomal recessive disease with a spectrum of systemic involvement. We sought to expand on the spectrum of variants and describe potential treatment.

Methods: We describe a case of newly diagnosed -related disorder, also known as H syndrome or familial histiocytosis, associated with CNS inflammatory pseudotumor and spinal cord compression.

An impressive case of isolated thoracic impalement.

Case: A 61-year-old male construction worker was admitted to our Emergency Department due to being impaled in the chest after fall onto the long pole of his cement mixer. He was promptly scanned through the CT then transferred to theatre where unique technique for intubation was utilised prior to performing a Video Assisted Thoracoscopic Surgery exploration and extraction of the foreign object.

Discussion: Impalement injuries are classified into Types I or II depending on the direction of movement of the human body in relation to the foreign object.

Ambulatory chest drainage with advanced nurse practitioner-led follow-up facilitates early discharge after thoracic surgery.

Objectives: To demonstrate the safety and feasibility of advanced nurse practitioner-led (ANP-led) outpatient follow-up after discharge with ambulatory chest drains for prolonged air leak and excessive fluid drainage.

Methods: Patients discharged with ambulatory chest drains between January 2017 and December 2019 were retrospectively reviewed. Discharge criteria included air leak < 200 ml/min or fluid drainage > 100 ml/24 h on a digital drain.

Acetazolamide treatment in late onset CDG type 1 due to biallelic pathogenic DHDDS variants.

Pathogenic variants in have been associated with either autosomal recessive retinitis pigmentosa or DHDDS-CDG. Heterozygous variants in have been described in patients with a progressive neurodegenerative disease. Here we report on an individual presenting with a multisystem CDG phenotype who was diagnosed with known homozygous pathogenic variants, previously associated with isolated retinitis pigmentosa.

Endobronchial Valves in the Management of Persistent Air Leak in Coronavirus Disease 2019.

Pneumothorax and persistent air leak are documented complications of severe acute respiratory syndrome coronavirus 2 infection. Patients who fall into this category are often poor candidates for invasive thoracic surgical intervention. Endobronchial valves offer an effective and less invasive treatment option and can successfully treat persistent air leak and support the weaning of patients with severe acute respiratory syndrome coronavirus 2 pneumonia off ventilation.

New N1/N2 classification and lobe specific lymphatic drainage: Impact on survival in patients with non-small cell lung cancer treated with surgery.

Objective: to validate the proposed N descriptor revision on a large cohort of patients and assess the impact of tumour location on the distribution pattern of lymph node metastases for patients with NSCLC.

Methods: This is a retrospective review of a consecutive series of patients who had anatomical lung resections. Systematic lymph node dissection was done for all patients.

Retrospective Observational Study into the Early Causes of Death Following Surgery for NSCLC.

Introduction: Respiratory failure has historically been the major cause of mortality after elective lung resections. With improved intubation using fiber-optic scopes, better preoperative respiratory risk assessment, more advanced anesthetic single lung ventilation, and minimally invasive surgical technique, this may have changed. Our objective was to assess the main causes of mortality over the past 10 years in patients undergoing elective lung surgery in a major UK center.

Prognostic factors including lymphovascular invasion on survival for resected non-small cell lung cancer.

Objectives: The aim of this study was to report on the influence of tumor lymphovascular invasion on overall survival and in patients with resected non-small cell lung cancer and identify prognostic factors for survival.

Methods: This is a retrospective observational study of a consecutive series of patients who had surgical resection of non-small cell lung cancer in a single institution. The study covers a 3-year period.

The Requirement of Sutures to Close Intercostal Drains Site Wounds in Thoracic Surgery.

Background: Chest drains are used routinely in thoracic surgery. Often a pursestring or mattress suture is used to facilitate closure of the defect on removal of the drain. This stitch can cause an unsightly scar, increase drain removal pain, and necessitate that the patient attend a community health care center to have this removed.

Does the addition of postoperative radiotherapy to adjuvant chemotherapy offer any benefit in patients with non-small cell lung cancer and mediastinal lymphadenopathy?

A best evidence topic in thoracic surgery was written according to a structured protocol. The question addressed was whether the addition of postoperative radiotherapy (PORT) to adjuvant chemotherapy offers any benefit in patients undergoing curative resection for non-small cell lung cancer found to harbour mediastinal lymphadenopathy. A total of 77 papers were identified using the reported search, of which 11 represented the best evidence to answer the clinical question.

New-onset atrial fibrillation after anatomic lung resection: predictive factors, treatment and follow-up in a UK thoracic centre.

Objectives: Postoperative atrial fibrillation (POAF) increases morbidity, hospital stay and healthcare expenditure. This study aims to determine the perioperative factors correlating with POAF as well as to evaluate both treatment strategies and AF persistence beyond discharge.

Methods: The records of all patients undergoing anatomical lung resection over a 1-year period were retrospectively reviewed.

Does the sequence of pulmonary vasculature ligation have any oncological impact during an anatomical lung resection for non-small-cell lung cancer?

A best evidence topic in thoracic surgery was written according to a structured protocol. The question addressed was 'in patients with primary lung carcinoma, does the sequence of pulmonary vasculature ligation during anatomical lung resection influence the oncological outcomes?' A total of 48 papers were found using the reported search, of which 7 represented the best evidence to answer the question. The authors, journal, date and country of publication, patient group studied, study type, relevant outcomes and results of these papers are tabulated.

Does the extent of resection affect survival in patients with synchronous multiple primary lung cancers undergoing curative surgery?

A best evidence topic was written according to a structured protocol. The question addressed was whether the extent of pulmonary resection affects survival in patients with synchronous multiple primary lung cancers undergoing curative surgery. A total of 724 papers were identified using the reported searches, of which 14 represented the best evidence to answer the clinical question.

[A complicated case of spontaneous oesophageal rupture managed by transgastric drainage].

Spontaneous rupture of the oesophagus is an extremely serious condition with high morbidity and mortality. Primary surgical repair may be followed by numerous complications. A 29-year-old man had undergone primary surgical repair due to spontaneous rupture of the lower third of the oesophagus.

[The treatment of spontaneous pneumothorax--focusing on the use of videothoracoscopy].

Aims: Videothoracoscopy plays a leading role in the management of spontaneous pneumothorax. This study evaluates various treatment strategies based on early results.

Patients And Methods: In a five-year period 243 (184 male, 59 female, mean age: 37.

[Expression of Ki-67 in bronchial asthma].

Unlabelled: In this paper we want to study the changes in the expression of cell proliferation factor Ki67 in the respiratory epithelium of patients diagnosed with bronchial asthma.

Material And Methods: Twenty one patients with bronchial asthma having different degrees of severity (according to GINA 2002) have been included in our study. Fragments of bronchial mucosa were obtained through fiberbronchoscopy, prepared for histologic examination in view of immune marking with anti-Ki67 antibodies.

[Intrathoracic migration of Kirschner wires].

Orthopedic surgeons apply metallic pins to stabilize the clavicule and humerus on a daily basis. Migration of these pins into the thoracic cavity is rare. We present the case of an elderly female patient, whose right humeroscapular joint was fixed with Kirschner wires due to recurrent luxation.

[Pulmonary thromboembolism: specifics of diagnosis in young age--case report].

Pulmonary thrombo-embolism (PTE) is responsible for a reasonable number of undiagnosed pleural effusions. It is considered that PTE causes pleural effusions more frequently than bronchogenic carcinoma although statistics bring it to less than 5% of diagnosed cases. This probably relies in an insufficient investigation of patients with pleural effusion as well as considering PTE a rare cause of disease.

[Expression of the Bax proapoptotic factor in asthmatic patients].

The alteration in the expression of the factors involved in the apoptotic mechanism of the respiratory cell epithelium of asthma patients remains an unsolved issue. The mitochondria holds a very important place in the apoptotic chain, making therefore the study of the proteins belonging to the Bcl-2 family that "controls" permeability of mitochondria's membrane extremely interesting, both for asthma as for other diseases. Our main concern in this study was to reveal the changes in expression of Bax factor at the level of the respiratory epithelium in asthma patients.

One- versus two-electron oxidation with peroxomonosulfate ion: reactions with iron(II), vanadium(IV), halide ions, and photoreaction with cerium(III).

The kinetics of the redox reactions of the peroxomonosulfate ion (HSO(5)(-)) with iron(II), vanadium(IV), cerium(III), chloride, bromide, and iodide ions were studied. Cerium(III) is only oxidized upon illumination by UV light and cerium(IV) is produced in a photoreaction with a quantum yield of 0.33 +/- 0.

[Abdominal hernia repair with No-React treated bovine pericardial patch].

Unlabelled: In the last decades surgical treatment of abdominal wall hernias has extensively developed. Tension free reconstruction is essential to the successful operation, which can be achieved in many cases only with the use of hernia patch or mesh. Synthetic materials gained widespread use for this purpose, which markedly reduced recurrence rate; but they can cause infections and other serious complications.