Publications by authors named "Verena Kehren"
The Rho-like GTPase Rac regulates distinct actin cytoskeleton changes required for adhesion, migration and invasion of cells. Tiam1 specifically activates Rac, and Rac has been shown to affect several signaling pathways in a partly cell-type-specific manner. Recently, we demonstrated that Rac activation inhibits Matrigel invasion of human carcinoma cells by transcriptional upregulation of tissue inhibitor of metalloproteinase-1.
View Article and Find Full Text PDFCharacterization of the 5' regulatory region of the Drosophila Dmdop1 dopamine receptor-gene.
Arch Insect Biochem Physiol
July 2005
The pharmacological and functional properties of many biogenic-amine receptors have been thoroughly investigated. In contrast, knowledge about the transcriptional regulation of receptor genes is limited. Here we describe the structural and functional properties of the promoter region of a dopamine receptor-gene (Dmdop1) from Drosophila.
View Article and Find Full Text PDFArticle Synopsis
- Saccharomyces cerevisiae and Candida albicans can switch between yeast and filamentous forms, with a specific gene, CaCCT8, identified in C. albicans that prevents this filamentous transition without affecting yeast growth.* -
- CaCct8p blocks certain pseudohyphal growth in S. cerevisiae induced by specific genes and conditions, while not inhibiting all forms of morphogenesis, indicating a selective role.* -
- Overproduction of CaCct8p in C. albicans effectively prevents hyphal growth under stress conditions, and disrupting CaCCT8 leads to issues with hyphal morphogenesis, suggesting its importance in the Ras2 signaling pathway.*