Fracture Behavior of Minimally Invasive, Posterior, and Fixed Dental Prostheses Manufactured from Monolithic Zirconia.

Objectives: To compare ultimate fracture load (F ), load at first damage (F ), and fracture pattern for posterior fixed dental prostheses (FDPs) manufactured from translucent, yttria-stabilized zirconia polycrystal.

Methods: Premolar-size FDPs in 4 test groups (n = 16/group) were constructed as veneered complete crown-retained (group 1), monolithic complete crown-retained (group 2), monolithic partial veneer crown-retained (group 3), or monolithic resin-bonded (group 4) prostheses with minimum zirconia wall thickness (0.5 mm).

Shifting the fermentative/oxidative balance in Saccharomyces cerevisiae by transcriptional deregulation of Snf1 via overexpression of the upstream activating kinase Sak1p.

With the aim to reduce fermentation by-products and to promote respiratory metabolism by shifting the fermentative/oxidative balance, we evaluated the constitutive overexpression of the SAK1 and HAP4 genes in Saccharomyces cerevisiae. Sak1p is one of three kinases responsible for the phosphorylation, and thereby the activation, of the Snf1p complex, while Hap4p is the activator subunit of the Hap2/3/4/5 transcriptional complex. We compared the physiology of a SAK1-overexpressing strain with that of a strain overexpressing the HAP4 gene in wild-type and sdh2 deletion (respiratory-deficient) backgrounds.