Publications by authors named "Verena Garsuch"

Solvent-free hot-melt coating processing is a novel and cost-efficient approach to manufacturing taste-masked multiparticulate systems. However, most API powders are fine and cohesive and not processable by hot-melt coating. The aim of this study was to produce dense and abrasion-resistant granules with high drug content (>80%) via roller compaction for hot-melt coating process optimization.

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Objectives: The aim was to compare different film-forming materials used for the preparation of fast-dissolving oral films.

Methods: Films were prepared with and without caffeine and caffeine citrate as model drugs. The disintegration/dissolution behaviour of films was investigated using the newly developed slide frame method and Petri dish method.

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This study aims at compensating the lack of adequate methods for the characterization of the novel dosage forms buccal wafers by applying recent advanced analytical techniques. Fast-dissolving oral wafers need special methods for assessing their properties in drug development and quality control. For morphologic investigations, scanning electron microscopy (SEM) and near-infrared chemical imaging (NIR-CI) were used.

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