Publications by authors named "Verena Adamer"
The title compound, 2-(3-cyano-4-iso-but-oxyphen-yl)-4-methyl-1,3-thia-zole-5-car-b-oxy-lic acid ethanol monosolvate, CHNOS·CHO, (I), displays inter-molecular O-H⋯O and O-H⋯N bonds in which the carboxyl group of the febuxostat mol-ecule and the hydroxyl group of the ethanol mol-ecule serve as hydrogen-bond donor sites. These inter-actions result in a helical hydrogen-bonded chain structure. The title structure is isostructural with a previously reported methanol analogue.
View Article and Find Full Text PDFHydrogen-bonded structures and interaction energies in two forms of the SGLT-2 inhibitor sotagliflozin.
Acta Crystallogr C Struct Chem
September 2017
Article Synopsis
- The sotagliflozin molecule exists in two different forms: one as a pure crystal (form 1) and the other as a monohydrate (form 2) that includes water.
- Both forms feature layers held together by hydrogen bonds, which involve three hydroxyl (-OH) groups in their structure.
- The molecular interactions in these layers differ, with the non-hydrogen-bonded interactions in both forms having higher energy compared to the hydrogen-bonded pairs, and each layer has a different geometric arrangement or topology.