[Risk factors of gastroduodenal bleeding in patients with severe burns].

An experience of treatment of 133 patients with severe bums was analyzed. Bleedings from the upper parts of the gastrointestinal tract were diagnosed in 16 patients in different terms since their admission to the hospital. At the moment of carrying out of the endoscopic research all bleedings were considered as taking place.

[Thermal preference and avoidance in cladoceran Daphnia magna strauss (Crustacea, Cladocera) acclimated to constant temperature].

The final preferable temperature (FPT) and avoidance temperature (AT) were determined in parthenogenetic females of the crustacean Daphnia magna Strauss. The animals were preliminary acclimated to constant temperature of 23.4 degrees C followed by keeping them in a thermo-gradient device for 24 days.

[Final thermal preference in parthenogenetic females of Daphnia magna Straus (Crustacea: Cladocera) acclimated to various temperatures].

The final thermal preference (FTP) range in parthenogenetic females of cladoceran Daphnia magna was assessed by "acute" and "chronic" methods. The first method included 4-month acclimation to different temperatures in the range of 14.2 +/- 0.

[Thermal and salinity tolerance of eurybiotic freshwater shrimp Gmelinoides fasciatus (Stebbing) under different acclimation conditions].

Critical thermal maximum and critical salinity maximum in their dependence on the water temperature and salinity were studied in the freshwater shrimps, Gmelinoides fasciatus, during their acclimation. Nine combinations of temperature (12.7-14.

[Population dynamics of Daphnia longispina (O.F. Müller, 1785) and Diaphanosoma brachyurum (Lievin, 1848) (Crustacea, Cladocera) under stable and graded temperature regimes].

Laboratory experiments have been performed to study the effects of different temperature regimes-constant (16.3 +/- 0.8, 20.

[The notion of ecological optimum and the determination of this optimum in freshwater poikilothermic animals].

The notion of ecological optimum is discussed as related to aquatic poikilothermic animals. Publications on the analysis of the influence of thermal factor on vital functions of invertebrates with the subsequent statement of the general pattern of optimal environmental factors are reviewed. It is concluded that the optimum includes not simply the range of the factor's values on the tolerance curve or the dose of the factor providing for the most favourable life conditions, but the oscillations of the factor within the optimum range, i.

[Use of the protocols of organization of the medico-diagnostic care for ulcerous gastroduodenal bleedings in clinical practice].

Results of realization of the protocols of organization of the medico-diagnostic care to patients with bleedings from chronic gastric and duodenal ulcers since 2002 have been analyzed. A simplified scale of the assessment of severity of ulcerous bleedings (UB) at admission including 8 criteria is proposed. Protocols of medical strategy for "severe UB" under conditions of the resuscitation unit are discussed.

[Morphology and electric instability of the myocardium in chronic coronary insufficiency].

Morphology and electric instability of the myocardium in patients with chronic coronary insufficiency have been studied in experiments on animals (rabbits), using a set of histological and histochemical techniques, and electron microscopy. Main aspects of myocardium reorganization at the subcellular, cellular, and tissual levels have been traced. The performed studies testify that the basic disturbances of the electric stability of the myocardium at chronic coronary insufficiency are based not upon some individual key pathogenic factor, but upon a series of alterations developing irregularly at all structural and functional levels of organization of the myocardium.

[Structural and metabolic aspects of heterogenicity of the ventricular cardiac myocytes in coronary insufficiency].

The paper shows comparative analysis of structural-metabolic changes of the ventricular cardiac hystiocytes during transitional restriction of blood supply, which leads to relapsing myocardium hypoperfusion, ischemia and even to cardiac infarction. We have established that an increase of the myocardium arrhythmogenicity, damage of myocardium electrophysiological activity and coronary deficiency are caused by pathologically intensified structural-metabolic heterogeneity of cardiomyocites. The chronic ischemic heart disease is worsening the situation by gradual accumulation of the metastructure changes of heart's working cells.

[Effect of long term administration of finoptin on the morphofunctional state of working cells of the intact myocardium in modeling of chronic coronary insufficiency].

In accordance with the findings on the key role of the cardiomyocite electrolyte homeostasis abnormality in dysfunction and coronary insufficiency-related alterative changes in the contractile myocardium and positive results of correction of the above abnormalities with Ca2+ antagonists morphofunctional aspects were studied of cardioprotective action of finoptin in its course administration in experiments in rabbits. General histological techniques were used together with transmission electron microscopy and cytochemical tests. The drug under study has been shown to increase the cardiomyocite glyco-calyx Ca(2+)-depositing function and to diminish its quickly-exchanging fraction on a plasmolemma.

[Morphofunctional aspects of cardioprotective effect of propranolol in modelling of chronic ischemic heart disease].

In experiments involving simulation of ischemic heart disease in adult rabbits, morphofunctional aspects were studied of cardioprotective action of propranolol on the contractile myocardium. With the aid of histological and histochemical, electron microscopic tests, the drug under consideration has been shown to be endowed with membrane-stabilizing properties, quite aside its receptor-mediated effects on Ca2+ metabolism known for. A decrease in its excessive ingress into the sarcoplasma comes, in its turn, to improve energy and plastic maintenance of the myocardial functions, to moderate a pathological reorganization and destructive changes in cardiomyocytes, thus promoting the contractile myocardium resistance to recurrent coronary crises.

[Ulcerous gastrointestinal bleedings].

On the basis of the study of 2388 patients with chronic gastric and duodenal ulcers complicated by acute bleeding, the most disputable organizational and tactical issues of ulcer bleeding (UB) treatment are discussed. It is reasonable to divide surgery for UB into urgent, delayed and elective. Indications for different surgeries in UB and basic surgical principles are discussed.

[Ultrastructure and metabolism of cardiomyocytes under experimental stress].

Morphogenesis of adaptational, disadaptational, and alterative changes affected structure and function of all live-supporting systems (contractile elements, macroergic phosphate synthesis, intracellular regeneration, and electrolyte exchange control) was studied in cardiomyocytes under experimental chronic stress using ultrastructural and cytochemical methods.

[The energy allowance and calcium homeostasis of the cardiomyocytes in the early stages of myocardial ischemia].

Morphofunctional equivalents are described of adaptive and abnormal reconstitution of CMC in acute coronary failure, using methods of light-transmission optics in combination with those of electron microscopy. It has been established that the contractile myocardium cell compensatory hyperfunction is provided by mobilization of a maximum number of the CMC organelles. Documented for the first time cytochemically is a direct interrelation between the metabolic activity of oxidoreductases, ability of mitochondria to accumulate Ca2+, and the status of their membranes.

[Prevention and treatment of stress-induced ulcers].

The data presented show that along with acid-peptic aggression an important role in pathogenesis of stress ulceration in the stomach and duodenum belongs to energy and immune deficiency which makes the correction of these alterations necessary. The timely and valuable conservative therapy including histamine H2-receptor blocking agents in addition to antacids and endoscopic electrocoagulation in case of profuse bleeding from stress ulcers allows to obtain hemostasis and healing of the ulcers more than in 90% of cases. When choosing the surgical method of treatment the preference should be given to atraumatic organ-preserving operations.