Biomarkers of basal cell carcinoma resistance to methyl-aminolevulinate photodynamic therapy.

Background: Methyl-aminolevulinate photodynamic therapy (MAL-PDT) is an excellent option for the treatment of basal cell carcinoma (BCC). However, up to 25% of cases are resistant to this treatment modality.

Objective: The aim of this study was to identify potential biomarkers of BCC response to MAL-PDT.

Comparative study of the clinical, histological, and biological characteristics of squamous cell carcinomas in areas previously treated with photodynamic therapy.

Although photodynamic therapy (PDT) is an effective treatment option for non-melanoma skin cancer, the development of aggressive tumours in PDT-treated areas has been described. To evaluate the clinical, histological, and biological characteristics of squamous cell carcinomas (SCCs) in areas previously treated with PDT vs those arising in areas never treated with this therapeutic modality. A retrospective observational study was designed.

Imiquimod and Photodynamic Therapy Are Useful in the Treatment of Porokeratosis in Children with Bone Marrow Transplantation.

Porokeratosis is an uncommon disorder that affects keratinization. Immunosuppression may favor the development of porokeratotic lesions. Patients who receive allogenic transplants represent a therapeutic challenge to dermatologists.

Cellular intrinsic factors involved in the resistance of squamous cell carcinoma to photodynamic therapy.

Photodynamic therapy (PDT) is widely used to treat non-melanoma skin cancer. However, some patients affected with squamous cell carcinoma (SCC) do not respond adequately to PDT with methyl-δ-aminolevulinic acid (MAL-PDT) and the tumors acquire an infiltrative phenotype and became histologically more aggressive, less differentiated, and more fibroblastic. To search for potential factors implicated in SCC resistance to PDT, we have used the SCC-13 cell line (parental) and resistant SCC-13 cells obtained by repeated MAL-PDT treatments (5th and 10th PDT-resistant generations).

Neuropeptide Y expression in cutaneous melanoma.

Background: Neuropeptide Y (NPY) is widely found in the nervous system and has a role in numerous physiologic processes. In addition, NPY receptors are expressed in neuroendocrine tumors, breast cancer, prostate cancer, kidney cancer, and some types of sarcomas. Different neuropeptides, particularly α-melanocyte-stimulating hormone (MSH), seem to play a role in the pathogenesis of melanoma.

Primary pure squamous cell carcinoma of the breast diagnosed by fine-needle aspiration cytology: a case study using liquid-based cytology.

Pure primary squamous cell carcinoma (SCC) is an extremely rare type of breast tumor. We report one of such cases in a 32-year-old woman, diagnosed by fine-needle aspiration cytology (FNAC). Aspiration smears were characterized by squamous cells, both isolated and in aggregates, at various stages of maturation.

Clear cell carcinoma of the ovary diagnosed in ascitic fluid. A case report.

Background: Clear cell carcinoma of the ovary (CCC) is a rare variety of ovarian cancer.

Case: A case of CCC in a 49-year-old woman was diagnosed in asciticfluid on thin-layer preparations. Peritoneal fluid cytology revealed papillary clusters of cells with clear cytoplasm and extracellular hyaline material generally without neoplastic cells.

Primary pulmonary botryomycosis diagnosed by fine needle aspiration cytology: a case report.

Background: Primary pulmonary botryomycosis is an uncommon suppurative bacterial infection of the lung. Cytologic findings by conventional methods and thin-layer preparations in1 case are presented.

Case: A 45-year-old man had primary pulmonary botryomycosis diagnosed by fine needle aspiration cytology (FNAC).

[Imiquimod in treatment of palpebral mycosis fungoides].

Clinical Case: Our patient was a 37-year-old male with palpebral mycosis fungoides, the most common T-cell cutaneous lymphoma. He had been treated previously with topical corticosteroids. We treated him with Imiquimod cream (5%) three times a week.

[Old schwannoma: a rare type of schwannoma].

Objectives: We report one case of retroperitoneal schwannoma with unfrequent histological characteristics evaluating its clinical significance and therapeutic options.

Methods: We report the case of a benign retroperitoneal schwannoma as an incidental MRI finding in a 70 year-old female patient with symptoms of lumbosciatic pain for 6 months. We perform a bibliographic review.

Dermal analogue tumor of the salivary gland diagnosed by fine needle aspiration cytology. A case report.

Background: Dermal analogue tumor of the salivary gland is a rare form of salivary gland adenoma. Cytologic and histologic findings of 1 case are presented.

Case: A 74-year-old-female had a dermal analogue tumor in the parotid gland diagnosed by fine needle aspiration cytology (FNAC).

Extramedullary plasmacytoma presenting as a primary mass in the breast. A case report.

Background: Extramedullary plasmacytoma (EMP) of the breast is extremely rare, especially that not associated with multiple myeloma.

Case: A case of plasmacytoma of the breast in a 73-year-old man was diagnosed by fine needle aspiration cytology (FNAC). Aspiration smears revealed a dispersed population of plasmacytoid cells at various stages of maturation.

[Sarcomatoid renal carcinoma. Report of 2 cases].

Objective: To describe two cases of sarcomatoid renal carcinoma, one of them is alive after five years from surgery.

Methods: Both patients had undergone radical nephrectomy, without complementary treatment.

Results: One patient is alive after five years; the second patient presented acute renal failure and died after five days from surgery.

Malignant phyllodes tumor with pleomorphic liposarcomatous stroma diagnosed by fine needle aspiration cytology: a case report.

Background: Liposarcomatous differentiation within a phyllodes tumor is extremely rare. Cytologic and histologic findings of a case of malignant phyllodes tumor with liposarcomatous stroma of the breast are presented.

Case: A 45-year-old female had a malignant phyllodes tumor with pleomorphic liposarcomatous stroma diagnosed by fine needle aspiration (FNA) cytology.

[Signet ring-cell adenocarcinoma in colocystoplasty].

We report a case of signet ring-cell adenocarcinoma in augmentation colocystoplasty. We review the current literature about tumours developing in augmentation bladder.

[Leiomyoma of the bladder].

Objective: To report a case of leiomyoma of the bladder, a benign tumor that accounts for 0.43% of bladder tumors. The literature is briefly reviewed.

[Intrascrotal epidermal inclusion cysts].

To del with a case of Intrascrotal epidermal inclusion cysts, clinical manifest like three scrotal masses. The patient was operated by transcrotally excision and he remains still asymptomatic. About this case and the terminology difficulties, we propose a differential diagnosis between different cystic lesion showed in the scrotum.

[Chromophobe renal carcinoma. Case report].

Human chromophobe renal cell carcinoma is an infrequent neoplasm, recently descripted (1985). It is very important to separate it from the renal cell carcinoma due to its better prognosis. Presentation of the clinical, radiographic and histological features of two cases of chromophobe renal cell carcinoma, diagnosed and treated in our Centre.