Publications by authors named "Vera Triunfante"
The extensive genetic diversity of HIV-1 is a major challenge for the prevention and treatment of HIV-1 infections. Subtype C accounts for most of the HIV-1 infections in the world but has been mainly localized in Southern Africa, Ethiopia and India. For elusive reasons, South Brazil harbors the largest HIV-1 subtype C epidemic in the American continent that is elsewhere dominated by subtype B.
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- The study highlights the issue of drug resistance mutations (DRM) to antiretroviral treatment (ART) in Brazil, where HIV prevalence is high and has seen an increase in the K65R mutation, particularly after switching from zidovudine to tenofovir in treatment regimens.
- Researchers found a significant rise in the K65R mutation from 2.23% to 12.11%, correlating with higher viral loads in patients harboring this mutation.
- There is a notable association between the K65R mutation and HIV-1 subtype C, indicating the need for careful monitoring of tenofovir-based treatment in populations with this subtype and specific HLA profiles.
The existing data support Portugal as the western European country with the highest HIV-1 subtype diversity. However, detailed phylogenetic studies of Portuguese HIV-1 epidemics are still scarce. Thus, our main goal was to analyze the phylodynamics of a local HIV-1 infection in the Portuguese region of Minho.
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