Novel synthetic adhesive as an effective alternative to Fibrin based adhesives.

Aim: To compare a novel, fully synthetic, polyurethane based glue (MAR-1) to fibrin sealant in a partial liver resection rat model.

Methods: After 50% resection of the lateral left liver lobe in male Wistar rats ( = 7/group/time point), MAR-1, Fibrin or NaCl was applied. After 14, 21 and 90 postoperative days, sealant degradation, intra-abdominal adhesions were scored, and histological examination of liver tissue was performed.