Publications by authors named "Vera Skripova"
Article Synopsis
- The study reveals that inhibiting KIT signaling in gastrointestinal stromal tumors (GISTs) activates the FGFR signaling pathway, leading to resistance against imatinib (Gleevec) despite no secondary mutations present.
- Long-term culture of imatinib-resistant GISTs shows reduced KIT expression and increased activation of FGFR signaling, making them more sensitive to pan-FGFR inhibitors like BGJ 398.
- The findings highlight that targeting the FGF-2/FGFR2 signaling pathway could be a promising strategy for overcoming imatinib resistance in GISTs.
NaPi2b is a sodium-dependent phosphate transporter that belongs to the SLC34 family of transporters which is mainly responsible for phosphate homeostasis in humans. Although NaPi2b is widely expressed in normal tissues, its overexpression has been demonstrated in ovarian, lung, and other cancers. A valuable set of antibodies, including L2 (20/3) and MX35, and its humanized versions react strongly with an antigen on the surface of ovarian and other carcinoma cells.
View Article and Find Full Text PDFThe chemoresistance of tumor cells is one of the most urgent challenges in modern oncology and in pancreatic cancer, in which this problem is the most prominent. Therefore, the identification of new chemosensitizing co-targets may be a path toward increasing chemotherapy efficacy. In this work, we performed high-performance in vitro knockout CRISPR/Cas9 screening to find potential regulators of the sensitivity of pancreatic cancer.
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