Publications by authors named "Vera Sergeeva"
Background: Comorbidities such as obesity and type 2 diabetes mellitus (T2DM) have emerged as critical risk factors exacerbating the severity and mortality of COVID-19. Meanwhile, numerous genome-wide association studies (GWAS) have identified single nucleotide polymorphisms (SNPs) associated with increased susceptibility to severe COVID-19.
Aim: This study investigated whether SNPs previously identified by GWAS as risk factors for severe COVID-19 also correlate with common comorbidities-obesity and T2DM-in hospitalized patients with severe COVID-19.
GWAS-significant loci and severe COVID-19: analysis of associations, link with thromboinflammation syndrome, gene-gene, and gene-environmental interactions.
Front Genet
August 2024
Objective: The aim of this study was to replicate associations of GWAS-significant loci with severe COVID-19 in the population of Central Russia, to investigate associations of the SNPs with thromboinflammation parameters, to analyze gene-gene and gene-environmental interactions.
Materials And Methods: DNA samples from 798 unrelated Caucasian subjects from Central Russia (199 hospitalized COVID-19 patients and 599 controls with a mild or asymptomatic course of COVID-19) were genotyped using probe-based polymerase chain reaction for 10 GWAS-significant SNPs: rs143334143 , rs111837807 , rs17078346 , rs17713054 , rs7949972 , rs61882275 , rs12585036 , rs67579710 , rs12610495 , rs9636867 .
Results: SNP rs17713054 was associated with increased risk of severe COVID-19 in the entire group (risk allele A, OR = 1.
Background: We investigated how syndromic versus nonsyndromic forms of micrognathia impacted difficult intubation outcomes in children. Primary outcome was the first-attempt success rate of tracheal intubation, secondary outcomes were number of intubation attempts and complications. We hypothesized that syndromic micrognathia would be associated with lower first-attempt success rate.
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- Olive anthracnose, caused by different species, leads to significant losses in olive fruit yield and oil quality globally.
- A thorough investigation of 185 isolates from olives and other hosts revealed varying pathogenicity and morphology, but phenotypic traits sometimes fell short of identifying all species accurately.
- Molecular techniques using specific gene regions (like ITS and TUB2) proved effective for species identification, with twelve species identified, showcasing notable virulence differences depending on the host and origin of the isolates.