Publications by authors named "Vera Schulz"
Cancer Biol Ther
March 2016
Article Synopsis
- MKP-1 plays a crucial role in breast cancer development and drug resistance, particularly against proteasome inhibitors like bortezomib.
- The study found that proteasome inhibitors lead to an increase in MKP-1 protein and mRNA levels specifically in breast cancer cells, mediated by p38 MAPK activation.
- Targeting MKP-1 with inhibitors or RNA interference enhances the effectiveness of proteasome inhibitors, suggesting that therapies aimed at reducing MKP-1 could improve treatment outcomes for breast cancer patients.
